81 results for “lymphocyte”

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Research ArticleOpen accessEvery word in the titleIn vitro Activation of Human and Rat Lymphocyte and Macrophage Functions by NorepinephrineRicardo Gomez-Flores, Diana Caballero-Hernandez, Richard J. Weber et al.Norepinephrine (NE) has been associated not only with increasing blood pressure, atherosclerosis, heart disease, and other life threatening conditions, but also with altering immune responses by influencing leukocyte functions. In the present study, we evaluated the in vitro effects of NE on rat thymic lymphocyte and human peripheral blood mononuclear cells (HPBMC) functions. We observed that NE marginally, but significantly … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 7,075 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleSelective Lymphocyte Activation and Inhibition of In Vitro Tumor Cell Growth by Novel MorphinansRicardo Gomez-Flores, Kimberly R. Vietti, William J. Dunn et al.Opioids can suppress immune functions and increase susceptibility to developing cancer and infectious diseases. Recently, novel opioid compounds have been synthesized that lack immunosuppressive effects. We evaluated the effects of morphinans with substituted pyrimidine (methyl, phenyl, hydroxy, and amino groups) and pyrazole groups on in vitro rat thymic lymphocyte and splenic macrophage functions, and tumor cell growth. We observed that … …American Journal of Immunology, Vol. 2, Issue 1 · 5 Mar 2005 · 7,078 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleAnalysis of Nucleoli in Intact Lymphocytes in Different Mammalian Species and HybridsBaylar Iolchiev, Pavel Klenovitskiy, Vugar Bagirov et al.The purpose of this study was to develop methods for quantitative and qualitative assessment of the activity of the nucleolus using the color intensity of argyrophilic regions and to study the effect of the species feature on the quantitative and qualitative indicators of the nucleoli and nucleolus organizer regions. The experiment involved Ovis aries (n = 40), hybrids of domestic … …OnLine Journal of Biological Sciences, Vol. 22, Issue 1 · 24 Jan 2022 · 6,069 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleInduction of Micronuclei in Mice Lymphocytes Exposed to Microwave and TolueneS. B. Mortazavi, A. Safari, A. Khavanin et al.Increasing applications of microwave radiation are of great concern with regard to public health. Several studies have been conducted detect effects of microwave exposure genetic material leading to negative or questionable results. The Micronucleus (MN) assay which is proved to be a useful method for detection of radiation exposure-induced cytogenetic damage was used in the present study to investigate the … …American Journal of Applied Sciences, Vol. 2, Issue 9 · 30 Sep 2005 · 6,614 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleComparing the Diagnostics Accuracy of CD4+ T-Lymphocyte Count and Percent as a Surrogate Markers of Pediatric HIV DiseaseMusie Ghebremichael, Haben Michael, Jack Tubbs, Elijah PaintsilThe percentage CD4+ T-lymphocytes is used to monitor pediatric HIV disease. However, in resource-limited settings, enumerating the percentage of CD4+ T-lymphocytes is hampered by the lack of laboratory infrastructure and trained technicians. In this paper, we investigated the performances of the percentage and absolute CD4+ T-lymphocytes as markers of pediatric HIV disease progression using data from HIV-infected children enrolled through … …Journal of Mathematics and Statistics, Vol. 15, Issue 1 · 3 Apr 2019 · 7,521 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleAccumulation of Cholesterol Esters in ex vivo Lymphocytes from Scrapie-susceptible Sheep and in Scrapie-infected Mouse Neuroblastoma Cell LinesAlessandra Pani, Claudia Norfo, Claudia Abete et al.Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie in sheep, revealed abnormal accumulation of cholesterol esters in brains and in ex vivo skin fibroblasts from genetically scrapie-susceptible, as compared to sheep with resistant genotype. We now report that PBMCs isolated from scrapie-susceptible sheep, as well as mouse neuroblastoma cell lines persistently infected with two different … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 6,955 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsCTLA-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients with Chronic Hepatitis C Under Interferon Alpha TherapySalwa M. Abo El-Khair, Abd El-Hameed A. Metwali, Mohamed Abd El-Maksoud, Tarek BesheerThyroid autoimmunity and dysfunction have reported as side effects of interferon-α treatment. The CT60 and exon 1+49 A/G polymorphisms in the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene have linked to susceptibility to autoimmune disease. The aim of this research was to analyze the frequencies of CTLA-4 CT60 and +49 A/G polymorphisms and evaluate both polymorphisms as indicators of thyroid disorder … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 3 · 20 Sep 2012 · 7,582 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsA 28 Years Old Woman with Severe Headache and Few Episodes of Vomiting: A Case ReportAhmad Reza Nakhayi, Tasnim Eghbal Eftekhaari, Hossein Montazerghaem et al.Problem statement: Cryptococcosis neoformans is commonest central nervous system infection in individuals infected with HIV. Most of the patients infected with Cryptococcus neoformans present with headache and visual changes. Approach: A 28 year old woman presented to Emergency Department (ED) with a chief complaint of headache, fever and vomiting and developed seizures during the first hour of admission. Firstly, diagnosed … …American Journal of Infectious Diseases, Vol. 6, Issue 4 · 31 Dec 2010 · 8,154 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsClinical Evidence of Autologous Graft versus Tumor EffectLuis F. PorrataProblem statement: The infused alloreactive lymphocytes in allogeneic stem cell transplantation (Allo-SCT) lead to an unspecific immune response causing Graft-Versus-Tumor (GVT) effect and Graft-Versus-Host Disease (GVHD). The current dogma regarding the anti-tumor effect of GVT is only observed in the Allo-SCT and not in the autologous hematopoietic stem cell transplantation (AHSCT). Approach: This article reviewed the medical literature to show … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Jan 2009 · 7,506 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,937 accessesView PDF Cite