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9 results for “lipid-lowering”
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Research ArticleOpen accessPhrase in the titleThe Lipid-Lowering Efficacy of Switching Within Non-Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected PatientsA.M. Bain, K.D. Payne, A.P. Rahman et al.The objective of present research is to evaluate the lipid lowering efficacy and safety of switching within non-nucleoside reverse transcriptase inhibitors (NNRTI) in HIV-infected patients. This is a multicenter, retrospective study utilizing a comprehensive electronic patient registry to identify all adult HIV-infected patients seen from October 1, 1998 through October 1, 2006, who substituted efavirenz for nevirapine (EFV→NVP) or vice-versa … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,743 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsIntracranial Atherosclerotic Disease: Treatment Potential and Diagnostic OpportunitiesAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Anton Yuvenalievich Postnov et al.Atherosclerosis, characterized by the accumulation of atherosclerotic plaques within large arteries, substantially increases the risk of cardiovascular events, including ischemic stroke. Intracranial atherosclerotic disease (ICAD) represents a particularly significant clinical threat given its strong association with ischemic stroke across multiple intracranial arterial territories. This review provides a comprehensive analysis of the pathogenesis, diagnosis, and management of intracranial atherosclerosis. Special attention … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 5 May 2026 · 1,093 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAnticonvulsant Effect of Pitavastatin in Mice Induced by PentylenetetrazoleKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipid-lowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,507 accessesView PDFCite
Review ArticleOpen accessIn the abstractBioactive Functional Foods for Cardiovascular DiseasesKiren Mustafa, Iqra Ajmal, Tahira Naz et al.Cardiovascular Disease (CVD) is a chronic pathological disorder regarded as a serious health concern round the globe. It is a multifactorial disease, with a range of various causative agents, among that dietary factor is considered the most important and may to a large degree determine CVD risk. Unfortunately, it has been less widely investigated. This review outlines the general aspects … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 17 Aug 2020 · 7,831 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in RatsMd. Yousuf Ali, Md. Reaz Morshed, Md. Sakib Hossen et al.In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxidant power. Administration of paracetamol (500 mg/kg) for seven consecutive days caused severe oxidative stress in … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 26 Nov 2018 · 8,337 accessesView PDFCite
Research ArticleOpen accessIn the abstractExploration of Antidiabetic and Hypolipidemic Activity of Roots of Croton ZambesicusPrakash Kumar, Rahul Kumar, Manoj Kumar Rastogi, Krishna MurtiThe aim of this study was to investigate the potential antidiabetic and hypolipidaemic effects of aqueous and ethanolic extracts of roots of Croton zambesicus in alloxan induced diabetic models to ascertain its pharmacological applicability. The roots of Croton zambesicus were collected, dried and extracted. The phytochemical screening as well as Median Lethal Dose determination (LD50) was done. The ethanolic extract … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 1 · 12 Jun 2017 · 7,851 accessesView PDFCite
Research ArticleOpen accessIn the abstractStatin Therapy in the Management of Diabetes Mellitus; How Relevant?Fasanmade Olufemi Adetola, Odeniyi Ifedayo AdeolaDiabetes is associated with the development of premature cardiovascular disease. There have been many clinical trials of statin treatment conducted in patients with Coronary Heart Disease (CHD). Taking a closer look at the subset of those patients with diabetes mellitus puts no doubt on the beneficial effect of lowering cholesterol with statin in these patients. Earlier studies done dwell more … …Current Research in Medicine, Vol. 4, Issue 1 · 25 Mar 2013 · 7,868 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in MiceKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methyl Glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality. Their lipid-lowering actions are by reversible and competitive inhibition of the enzyme HMG-CoA reductase, a precursor of cholesterol. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels, such as … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,679 accessesView PDFCite
Research ArticleOpen accessIn the abstractEfficacy of Pravastatin in Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) and Protease Inhibitor (PI)-based HAART in HIV-Infected PatientsSusan A. Eaton, Anita P. Rahman, Sean T. Nguyen et al.Pravastatin has generally been considered a safe and effective option for HIV-infected patients on highly active antiretroviral therapy (HAART). However, pravastatin concentrations are known to significantly decrease with concomitant efavirenz (EFV) use. Currently there are no studies determining if these reductions in pravastatin possibly translate into an attenuation of its lipid lowering efficacy when used in HIV-infected patients on non-nucleoside … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,959 accessesView PDFCite