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Research ArticleOpen accessEvery word in the titleCreation of Tetracycline Regulatable Knockouts of ORFF Gene from the LD1 Locus of Leishmania donovaniBindu Sukumaran, Manju Jain, Peter J. Myler et al.The tetracycline repressor/operator system was adapted for use in Leishmania donovani. In order to investigate the possible importance and function of open reading frame F (ORFF) in Leishmania donovani strain AG83 that has a single copy of ORFF in the LD1 locus on chromosome 35, we have attempted to generate tetracycline regulatable single allele mutants of ORFF. Leishmania cells expressing … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,832 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,941 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleKnock Down of Erythrulose Kinase (eyk1) Leads to the Enhancement of Erythritol Production in Yarrowia lipolytica Mutant Strain YE4-2Xinhe Zhao, Tianlong Huang, Yaxin Zhang et al.Erythritol is a nearly zero-calorie sweetener, which is in great demand in food and health care industry. Our previous work obtained a Yarrowia lipolytica mutant strain YE4-2 with high erythritol yield. However, its conversion rate of glucose needs further improvement. Erythrulose kinase (eyk1) participates in the early stages of erythritol catabolism; the existence of eyk1 prevents the accumulation of erythritol. … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 24 Jul 2020 · 6,753 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDietary supplementation with Cyperus esculentus L (tiger nut) tubers attenuated atherosclerotic lesion in apolipoprotein E knockout mouse associated with inhibition of inflammatory cell responsesMohamed L. Salem, Mohsen Zommara, K. ImaizumiAtherosclerosis is a pathological process, where recruitment of mononuclear cells results in the growth of fibro-fatty plaques. Apolipoprotein E (ApoE) is a legend for the uptake of lipoproteins, and deficiency of ApoE leads to the accumulation of low-density lipoprotein. Utilizing ApoE-/- mouse, which spontaneously develop atherosclerosis on low-fat chow diets, the present study showed that feeding these mice on a … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 10,479 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRole of Biopterin Transporter (BT1) Gene on Growth and Infectivity of LeishmaniaManju Jain, Vandana S. Dole, Peter J. Myler et al.Leishmania are known to be auxotrophic for pteridines that are known to play a critical role in the parasites survival. In the present work the role of biopterin transporter in the growth of the parasite and infectivity in to macrophages has been worked out. The role of biopterin transporter in the susceptibility of Leishmania to antimonial compounds has also been … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,040 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Quasi One-dimensional Simulation of a 4 Stroke Spark Ignition Hydrogen Fuelled EngineT. F. Yusaf, M. Z. Yusoff, I. Hussein, S. H. FongActive research and development of hydrogen-fuelled engine had been done for a few decades since hydrogen serves as a potential of infinite fuel supply. This paper discussed analytically and provides data on effects of compression ratio, equivalence ratio and spark timing of a hydrogen-fuelled engine as a guideline for the engine design. The change in the thermodynamic properties of the … …American Journal of Applied Sciences, Vol. 2, Issue 8 · 31 Aug 2005 · 6,887 accessesView PDFCite
Review ArticleOpen accessIn the keywordsOverview of the Most Popular Currently Used Murine Models of AtherosclerosisAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Alexandra Alexandrovna Melnichenko et al.Atherosclerosis is a widespread and serious problem. Every year it causes a huge number of deaths and morbidity. Many aspects of this disease remain not fully understood, which indicates the need to search for the most representative model of atherosclerosis in animal and cell culture models. Animal models resembling the pathophysiology in humans are needed to study the immunometabolic mechanisms … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 4 Jan 2024 · 4,673 accessesView PDFCite
Research ArticleOpen accessIn the abstractATRA AS A POTENTIAL ANTIMETASTATIC AGENT IN COLORECTAL ADENOCARCINOMARobert Edwards, Kambiz Afrasiabi, Kehui WangThe family of Retinoic acid compounds have long been the subject of intense study and interest as chemo prophylactic agents. This dates back to their therapeutic effect in leukoplakia Where ATRA was shown to lead to the reversal of premalignant lesions and Subsequent reports on their use in metastatic colorectal adenocarcinoma and a vast array of other malignant disorders as … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 26 Mar 2014 · 7,348 accessesView PDFCite
Research ArticleOpen accessIn the abstractTRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES-AMAZING TOOL FOR GENOME EDITINGAvantika Singh, Vivek Pratap SinghTranscription Activator-Like Effector Nucleases (TALENs) are used to cut specific target DNA sequence in order to knock out a gene or to change its sequence. They are formed by the fusion of TALE protein serving as DNA binding domain along with non-specific DNA cleaving nucleases. Its specificity towards DNA bases in the target sequence is derived from the structure of … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 8,000 accessesView PDFCite
Research ArticleOpen accessIn the abstractHYPOXIC INFLAMMATION, A DEADLY BRIDGE TO MALIGNANT TRANSFORMATION AND A FERTILE SOIL FOR CANCER PREVENTIONKambiz Afrasiabi, Robert Edwards, Jonathan Melekh-Shalom, Kehui WangThe interplay of the inflammatory microenvironment with its hypoxic niche and the potential mechanism by which they lead to malignant transformation has long been the subject of great controversy and continues to be an area of great interest today. In our previous studies we have examined this subject by using Gia2 knock out mice as the focus of our research. … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 7,149 accessesView PDFCite