11 results for “highly active antiretroviral therapy”

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Research ArticleOpen accessPhrase in the titleHigh Frequency of Stop Codons in the Human Immunodeficiency Virus-1 Protease Gene Frame in Human Immunodeficiency Virus+ Individuals with Below Detectable Levels of Plasma Viremia During Highly Active Antiretroviral TherapyMagdalena Czubala, Kabo Matlho, Maria Arriaga et al.We performed sequence analysis of HIV-1 proviral protease gene fragment (560 base pairs) amplified from ex-vivo peripheral blood mononuclear cells of 83 HIV+ individuals with Below Detectable Levels (BDL) (<20-40 RNA copies/ml plasma) and detectable levels of plasma HIV viremia while on HAART. Noteworthy was the systematic presence of stop codons identified only in the BDL group and not in … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 14 Nov 2012 · 8,073 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsThe Effects of Protease Inhibitors on Metabolic Complications and Lipodystrophy in Human Immunodeficiency Virus-Infected PatientsMohd Khaza, K. Laxmi Prasad, M. EstariProblem statement: Highly Active Antiretroviral Therapy (HAART)-associated metabolic complications include lipoatrophy (loss of Subcutaneous Adipose Tissue (SAT) and insulin resistance. The risk of Diabetes Mellitus (DM) in Human Immunodeficiency Virus (HIV)-infected patients receiving Highly Active Antiretroviral Therapy (HAART) especially protease inhibitors has not been well defined. Approach: We conducted an analysis in the Hospital of Rajeev Gandhi Institute of Medical … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 6,934 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsEfficacy of Pravastatin in Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) and Protease Inhibitor (PI)-based HAART in HIV-Infected PatientsSusan A. Eaton, Anita P. Rahman, Sean T. Nguyen et al.Pravastatin has generally been considered a safe and effective option for HIV-infected patients on highly active antiretroviral therapy (HAART). However, pravastatin concentrations are known to significantly decrease with concomitant efavirenz (EFV) use. Currently there are no studies determining if these reductions in pravastatin possibly translate into an attenuation of its lipid lowering efficacy when used in HIV-infected patients on non-nucleoside … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,959 accessesView PDF Cite

EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDF Cite

Research ArticleOpen accessIn the abstractNevirapine Hepatotoxicity: Implications of Risk FactorsElias Adikwu, Oputiri Deo, Oru-Bo Precious Geoffrey, D. Akuegbe EnimeyaHighly active antiretroviral therapy is used in the management of HIV/AIDS; it has contributed tremendously in the reduction of mortality and morbidity rate in HIV patients. Despite the outstanding achievement with the use of HAART its major limitation is toxicity. Among these toxicities is hepatotoxicity which is said to be associated with nevirapine containing highly active antiretroviral therapy. Recent reports … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 3 Jun 2013 · 7,653 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn-Depth Review of Human Immunodeficiency Virus-Associated NephropathySira Korpaisarn, Wisit Cheungpasitporn, Daych Chongnarungsin et al.Human Immunodeficiency Virus (HIV)-Associated Nephropathy (HIVAN) is one of the most important renal complications found in HIV-infected individuals. Morbidity and mortality in this group of patients increases due to End-Stage Renal Disease (ESRD). Classic histological characteristics of HIVAN are collapsing Focal Segmental Glomerulosclerosis (FSGS), microcystic tubular dilation and interstitial inflammation and fibrosis. High prevalence of HIVAN among people of African … …Current Research in Medicine, Vol. 4, Issue 1 · 19 Apr 2013 · 7,360 accessesView PDF Cite

Research ArticleOpen accessIn the abstractConcentration-Effect, Incidence and Mechanism of Nevirapine HepatotoxicityAdikwu Elias, Brambaifa NelsonNevirapine is a dipyridozepinone non nucleoside reverse transcriptase inhibitor approved for use in HIV-infected patients. Its efficacy has been well demonstrated in numerous clinical trials. It has activity against HIV-1 but does not have significant activity against HIV-2 or other retroviruses. Nevirapine is used as one of the components of highly active antiretroviral therapy in HIV patients and in the … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 19 Apr 2013 · 8,156 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInduction of a Soluble Anti-HIV-1 factor (s) with IFN-γ, IL-10, and β-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic MixtureJosé W. Rodríguez, Nat O. Pagan, Mar C. Ocasio et al.Partial immune restoration may be obtained with highly active antiretroviral therapy (HAART), but specific anti-HIV-1 immune responses do not appear to improve substantially. We have demonstrated that a soluble factor(s) induced by a mixture of inactivated influenza and bacterial vaccines called polyantigenic immunomodulator (PAI), possesses strong immunoregulatory and anti- HIV-1 activities. In the present study, we show that culture fluids … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,845 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAbnormal Glucose Regulation and Treatment Strategies for Insulin Resistance HIV-Infected PatientsSteven GrinspoonHIV-infected patients receiving highly active antiretroviral therapy often demonstrate abnormalities in glucose regulation, in association with changes in fat distribution[1,2]. In the majority of cases, these abnormalities are best characterized by insulin resistance and impaired glucose tolerance, rather than overt diabetes mellitus and fasting hyperglycemia. Insulin resistance may result from direct effects of antiretroviral therapy, changes in fat distribution or … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,387 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRecreational Viagra Use and Sexual Risk among Drug Abusing MenDennis G. Fisher, Robert Malow, Rhonda Rosenberg et al.Until recently, the Viagra connection to HIV was anchored in older adults. However, CDC investigation showed stability in 50+ HIV diagnoses on the heels of upward trends in risk indicators among men who have sex with men (MSM) and substance abusing populations. Signs have increasingly pointed to recreational drug use among younger populations, to which Viagra is being added to … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 10,605 accessesView PDF Cite