7 results for “glucocorticoids”

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Literature ReviewOpen accessEvery word in the titleThe Effects of Glucocorticoids on Trabecular Meshwork and its Role in GlaucomaAlina GenisPrimary Open-Angle Glaucoma (POAG), an optic neuropathy that is a leading cause of irreversible blindness, has been studied extensively in hopes of better understanding its underlying mechanism. Glucocorticoids (GC) are commonly used to treat inflammatory ocular conditions but are also known to increase the risk of glaucoma by raising Intraocular Pressure (IOP) in susceptible individuals, leading to steroid-induced glaucoma. Based … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 14 Oct 2015 · 8,219 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsMaternal Infection and Neurodevelopmental Disorders in the OffspringHeping ZhouProblem statement: Neurodevelopmental disorders such as schizophrenia and autism have been attributed to both genetic and environmental factors. Whether and how maternal infection as an environmental factor contributes to the development of neurological abnormalities in the offspring remains to be clearly defined. Approach: The literature was reviewed to examine the relationship between maternal infection and neurological disorders such as schizophrenia … …American Journal of Immunology, Vol. 8, Issue 1 · 12 Mar 2012 · 8,150 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsEffect of Stevia Consumption on Blood Pressure, Stress Hormone Levels and Anthropometrical Parameters in Healthy PersonsEmad A.S. Al-Dujaili, Husni Twaij, Yazan A. Bataineh et al.Stevia is a natural sweetener containing steviol glycosides known to be several times sweeter than sucrose. It is thought to have several beneficial properties though some evidence state it may have detrimental effects. The aim of this study was to investigate the potential beneficial or harmful effects of stevia consumption by exploring its effects on blood pressure, stress hormone levels … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 1 · 31 Aug 2017 · 25,775 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsEffect of Niacin on Hyperleptinemia and Ob Gene mRNA Over-Expression in Adipose Tissue of Dexamethasone Treated RatsTahoora Shomali, Mahnaz Taherianfard, Mehdi Fazeli, Niloofar SafaeiProblem statement: Glucocorticoid-induced ob gene over-expression and resulted hyperleptinemia may lead to adverse consequences especially on cardiovascular system; therefore, the present study was conducted to evaluate the effects of niacin on hyperleptinemia and ob gene over-expression due to dexamethasone administration in rats. Approach: Twenty four adult male rats divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 7,988 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAmphetamine Stimulates Protein Kinase and Calcium Influx to Increase Corticosterone and Aldosterone Secretion from Male Rat Adrenal CellsLing-Ling Chang, Wan-Song Alfred Wun, Cai-Yun Jian, Paulus S. WangAmphetamine is a potent central nervous system stimulant. Clinical trials have demonstrated that in healthy adults, low (therapeutic) doses of amphetamine can improve i.e., cognition, memory, attention behavior. An amphetamine overdose can affect cardiovascular, central nervous system, musculoskeletal, respiratory, urinary, or sexual function. Furthermore, amphetamine can activate the hypothalamic-pituitary-adrenal axis to increase glucocorticoids and mineralocorticoids released from adrenal. The object … …American Journal of Pharmacology and Toxicology, Vol. 16, Issue 1 · 10 Mar 2021 · 7,872 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOsteoporosis Induction in Animal ModelKamran Kaveh, Rashid Ibrahim, Mohd Zuki AbuBakar, Tengku Azmi IbrahimProblem statement: Osteoporosis; the major health problem is an imperative disease requires a significant attention to discover different aspects of this threatening abnormality. There are some problems in osteoporotic human population to conduct researches such as lack of a homogenous sample size or ethical problems. So, there was a need to have protocol in animal model to let the scientists … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 2 · 30 Jun 2010 · 9,305 accessesView PDF Cite

Research ArticleOpen accessIn the abstractHormetic and Non-Hormetic Dose-Response Functions in Stress Effects on Memory and Synaptic Plasticity: Issues and MechanismsPhillip R. Zoladz, David M. DiamondOver a century of behavioral research has shown that stress can exert both positive and negative effects on memory. We have explored the idea that the complex effects of stress on learning and memory can be characterized by hormetic- and non-hormetic dose-response functions, in which stress may either stimulate or impair brain memory mechanisms, depending, in part, on the timing … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,184 accessesView PDF Cite