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36 results for “elevated serum”
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Research ArticleOpen accessIn the keywordsAnticonvulsant Effect of Pitavastatin in Mice Induced by PentylenetetrazoleKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipid-lowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,449 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Vitamin E on Stress Resorption, Lipid Profile and Reproductive Performance of Sokoto Red GoatsKehinde Matthias OKUKPE, Ling Shing Wong, Geetha Subramaniam et al.Vitamin E (α-tocopherol) plays a critical role in animal nutrition as an antioxidant, contributing to anti-inflammatory responses, immune function, and gene expression regulation. This study aimed to determine the optimal dietary level of vitamin E to alleviate the effects of environmental stress in Sokoto Red Goats transported from their native dry savannah belt to the humid derived savanna belt of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 20 Mar 2026 · 1,509 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluating the Hepatoprotective and Anti-Inflammatory Efficacy of Herbal Extracts for NAFLD PreventionHessah Mohammed Al-Muzafar, Kamal Adel AminNatural products may offer a safer approach for mitigating the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD). This study aimed to evaluate the hepatoprotective and anti-inflammatory effects of a water-based extract of Moringa Oleifera leaf, Milk Thistle, and Cassia (MO-MT-CA) against High-Fat, High-Sugar Diet (HFSD)-induced fatty liver. The research focuses on assessing lipid profiles and inflammation as key markers … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 23 Nov 2025 · 1,968 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdipose-Derived Canine Mesenchymal Stem Cells in PLAY® MediaArjun Kulkarni, Bhavana N. V., Teena Mary Thomas et al.In veterinary medicine, stem cell-based therapies present promise for addressing orthopedic and degenerative conditions in canines. Mesenchymal Stem Cells (MSCs) possess unique regenerative, immunomodulatory, and differentiation capabilities. However, their efficacy relies on optimal in-vitro conditions. Prolonged expansion over passages leads to a gradual loss of stem cell traits, highlighting the importance of optimized culture conditions and media supplements. This study … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 3 · 13 Jul 2024 · 5,598 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Impact Of TLR9 Antagonist ODN 2088 Against Carbon Tetrachloride (CCl4)-Induced Hepatic InjuryBadr AlzahraniThe main objective of this study is to evaluate the hepatoprotective impact of TLR9 antagonist ODN 2088 against carbon tetrachloride (CCl4)-induced acute liver injury. In this study, 24 mice were grouped into four groups. CCl4 was introduced in all groups except for the control group intraperitoneally after pretreatment with ODN 2088 and silymarin for seven days. To assess the liver … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 4 Jan 2020 · 7,659 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Influence of Garcinia kola Seed on Sexual Behavior and Testis Physiology in Wistar RatsJonah Sydney Aprioku, Victor Nwachukwu, Blessing Ukamaka Okeke et al.Garcina kola seed is believed by some to enhance male sexual performance but existing scientific data show divergent results. In this study, the sexual and reproductive influence of ethanol (70%) seed extract of G. kola was evaluated in Wistar rats. Adult male rats were gavaged with 0, 50, 100, 200 or 300 mg kg-1 day-1 of extract for 30 days … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 25 Apr 2018 · 13,804 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractSerum Ornithine Carbamoyltransferase Activity and Correlation with Fatty Liver in Dairy Cows with Displaced AbomasumKen Onda, Reiichiro Sato, Yosuke Sasaki et al.Ornithine Carbamoyltransferase (OCT) is a hepatocyte-specific enzyme; elevated serum activity indicates liver damage. Displaced abomasum frequently occurs around the time of parturition in dairy cattle and is associated with fatty liver. We analyzed serum OCT activities to investigate the relationship between displaced abomasum and fatty liver. Lactating Holstein cows, 75 clinically healthy and 22 with displaced abomasum, were used. Serum … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 3 · 13 Jul 2016 · 7,660 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelationship between Anti-Ds-DNA Antibodies and Abnormal Kidney Function Tests in Patients with Lupus NephritisFalah Salim Manhal, Hawra'a Adnan MohammedThe majority of patients with Lupus Nephritis (LN) usually have abnormal findings of kidney function tests. Severe glomerular damage may be observed in some patients and requires prompt therapeutic interventions. High titer levels of anti-ds-DNA antibodies may correlate to some extent with disease activity in lupus nephritis patients. The purpose of this study was to evaluate the relationship between anti-ds-DNA … …American Journal of Immunology, Vol. 12, Issue 2 · 21 May 2016 · 9,076 accessesView PDFCite