72 results for “drug resistant”

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Research ArticleOpen accessPhrase in the titleOutcomes and Risk Factors Associated with Drug Resistant Tuberculosis in Rural Eastern Cape, South AfricaCarine Bokop Fotso, Sandeep D. Vasaikar, Teke ApalataWith the emergence of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) strains of Mycobacterium tuberculosis, Tuberculosis (TB) has become an even greater threat in South Africa (SA). The study sought to investigate the resistance pattern of anti-TB drugs in M. tuberculosis as well as to determine the associated risk factors and outcomes for MDR-TB and XDR-TB. A descriptive study was conducted … …American Journal of Infectious Diseases, Vol. 14, Issue 2 · 15 Aug 2018 · 9,536 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleMycobacterium tuberculosis Complex Mutations in Drug Resistant Clinical Isolates from Southwest MexicoMartínez-Cruz Perla Mónica, Nakamura-López Yuko, Quintero-Hernández Verónica et al.Mutations in target genes have been described in Mycobacterium tuberculosis Complex (MTBc) drug resistant isolates worldwide. In Mexico, not enough information has been reported in this concern. The aim of this study was to characterize mutations related to resistance to first line drugs in MTBc isolates from Oaxaca, Mexico. MTBc isolates were identified in clinical samples from Tuberculosis (TB) patients. … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 28 Oct 2021 · 6,667 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleDetermination of Optimum Values of Descriptors to Set Filters for Synthetic Tri-Pyrrole Derivatives (Prodiginines) Against Multi Drug Resistant Strain of Plasmodium FalciparumVijay H. Masand, Devidas T. Mahajan, Eslam Pourbasheer et al.In the present study, we have carried out extensive non-linear Quantitative-Structure Activity Relationship (QSAR) analysis to correlate in vitro anti-malarial activity against multi drug resistant strain of Plasmodium falciparum. Forty-three synthetic prodiginines with different structural features were used for their potential antimalarial activity. Linear, bilinear, biexponential and parabolic equations were developed. These equations were compared to determine the optimum values … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,141 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleSYNERGY OF A NOVEL ANTIBIOTIC ADJUVANT ENTITY AGAINST MULTI DRUG RESISTANT ENTEROBACTERIACEAEManu Chaudhary, Anurag PayasiIn the present investigation, we investigated the in vitro interaction of ceftriaxone plus sulbactam with disodium edetate, a Non Antibiotic Adjuvant (NAA) against selected clinical isolates and in vitro susceptibility studies were also performed. The isolates were tested against a range of ratios of ceftriaxone and sulbactam using a microdilution checkerboard method. Having determined the appropriate ratios of ceftriaxone plus … …American Journal of Infectious Diseases, Vol. 9, Issue 3 · 1 Nov 2013 · 7,416 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titlePassive Transfer of HIV-1 Antibodies and Drug Resistant Virus during a Health Care Worker Accident: Implications for HCW Post-Exposure ManagementCarlos Fernando De Oliveira, Ricardo Sobhie Diaz, Abdallah Harmache et al.Problem statement: We studied in detail a case in which a nurse caring for an HIV-infected child suffered a deep-laceration accident with contaminated blood. Approach: The patient had been treated with zidovudine (ZDV) and the nurse became infected despite prophylactic use of ZDV initiated 2 h after the accident. A reactive anti-HIV-1/2 EIA and an indeterminate western blot (gp120/160 reactivity) … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,872 accessesView PDF Cite

Review ArticleOpen accessPhrase in the titleHerbal Compounds-An Alternative for Multi-Drug Resistant Vibrio CholeraeSabah Perveen, Hotam Singh ChaudharyVibrio cholerae is a causative agent of cholerae, many people dies every year, especially in developing countries around the world. The outbreaks of cholera are responsible for approximately 120,000 deaths annually. Cholera is a self limiting illness; however antibiotics are used as a part of treatment regimen. But at present, the treatment against cholera has become very critical issue worldwide, … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 12 Oct 2015 · 7,260 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleDiatrizoate, Iopromide and Iotrolan Enhanced Cytotoxicity of Daunorubicin in Multidrug Resistant K562/adr Cells: Impaired the Mitochondrial and Inhibited the P-Glycoprotein FunctionNitaya Snitwongse Na Ayudhya, Samlee MankhetkornMultidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as P-glycoprotein (P-gp). This study observed some iodinated radiographic contrast media, diatrizoate, iopromide and iotrolan affected the cellular energetic state and the kinetics of P-gp in drug-sensitive K562 and drug resistant K562/adr cell lines using spectrophotometer and spectrofluorometer. … …American Journal of Applied Sciences, Vol. 6, Issue 3 · 31 Mar 2009 · 7,161 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleScreening of Multi-Drug and Metal Resistant Aeromonas Species from Diverse SourcesRamasamy Amsaveni, Muthusamy Sureshkumar, Joseph Reshma Mary et al.The abuse of antibiotics in the modern era, lead the microorganisms to develop resistance. Antibiotic resistance becomes the part of natural selection in bacteria which allows them to survive in different environments. Bacteria like Aeromonas are able to adapt to changes in the environment such as an increase in antibiotic concentration, which often results in the development of mutations allowing … …American Journal of Infectious Diseases, Vol. 11, Issue 2 · 7 Aug 2015 · 7,575 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleCirculation of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium Tuberculosis Strains in MexicoCarlos A. Vazquez-Chacon, Armando Martinez-Guarneros, Susana Balandrano Campos et al.Emergence of Extensively Drug-Resistant (XDR) Tuberculosis (TB) is an important public health problem worldwide. In Mexico, the extent of circulation of XDR-TB strains is unknown. Here, the drug-resistance patterns of TB isolates collected in Mexico between 2006 and 2008 were analyzed. Among 137 TB isolates, (58%) were classified as MDR exclusively, (33%) were Pre-XDR and (9%) were assigned as XDR. … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 7,422 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titlePrevalence of Drug-Resistant Strains of Streptococcus Pneumoniae in AbakalikiIroha Ifeanyichukwu Romanus, Okafor Florence Njideka, Nwakaeze Emmanuel Amobi et al.Streptococcus pneumoniae is a major cause of illness such as pneumonia, meningitis, bacteremia and otitis media in children and the elderly. The emergence of drug-resistant strains threatens to complicate the management of these diseases. We conducted a hospital-based surveillance for drug-resistant Strep. Pneumoniae in outpatients with pneumococcal infection in Abakaliki Ebonyi State Nigeria. Between 2003-2005 from January through December, a … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 26 Nov 2012 · 7,677 accessesView PDF Cite