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53 results for “drug interaction”
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Review ArticleOpen accessPhrase in the titleDrug Interactions Pharmacology: A Narrative ReviewLívia Maria Barbosa Neves, Louryanne de Castro Silva, Mônica Thalia Brito de Melo et al.Thesimultaneous prescription of multiple drugs used in therapeutic schemes canresult in drug interactions, with desirable or undesirable effects. Thus, theobjective of this study was to describe the mechanisms involved in clinicallyrelevant drug interactions. This is a narrative review in which studiespublished in PUBMED and the VHL were searched in the following databases:MedLine, Lilacs, and Scielo. The search was performed in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 25 Oct 2022 · 9,157 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleDrug Interaction between Salinomycin and Exogenous Adrenaline in DogsHamid Rajaian, Javad Sajedianfard, Saeed Nazifi, Ali Moosavi KianProblem statement: Salinomycin is a member of ionophore compounds that may be used in ruminants and pigs as growth promoter or to prevent coccidiosis. There are some reports with respect to the in vitro and in vivo sympathomimetic cardiovascular effects of salinomycin. Available reports indicate that adrenergic impact of the ionophore is brought about by an increase in the secretion … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 2 · 30 Jun 2009 · 7,541 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Drug-Target Interaction Prediction Based on Supervised Probabilistic ClassificationManmohan Singh, Susheel Kumar Tiwari, G. Swapna et al.Bayesian ranking-based drug-target relationship prediction has achieved good results, but it ignores the relationship between drugs of the same target. A new method is proposed for drug-target relationship prediction based on groups by Appling Bayesian. According to the reality that drugs interacting with a specific target have similarities, a grouping strategy was introduced to make these similar drugs interact. A … …Journal of Computer Science, Vol. 19, Issue 10 · 1 Sep 2023 · 5,454 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHydrophobic, Polar and Hydrogen Bonding Based Drug-Receptor Interaction of TetrahydroimidazobenzodiazepinonesV.K. Sahu, A.K.R. Khan, R.K. Singh, P.P. SinghAnti-HIV drug discovery has been increasingly focusing on HIV-1-RT (reverse transcriptase) as a potential therapeutic target. Tetrahydroimidazobenzodiazepinone (TIBO) belongs to non-nucleoside group of reverse transcriptase inhibitors (NNRTIs). A computational chemistry study has been performed on a series of tetrahydroimidazo-benzodiazepinones as HIV-1-NNRT inhibitors. Problem statement: In order to search out new drug of desired activity from the lead compounds, there was … …American Journal of Immunology, Vol. 4, Issue 3 · 30 Sep 2008 · 8,837 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIdentification of Microbe-Drug Association based on Weighted Profile and Collaborative Matrix FactorizationZhu Ling-Zhi, Guixiang Li, Chunhua Li, Jun WangPrevious studies have shown that diseases are associated with microbe. To explore a more effective treatment for these diseases, unknown microbe-drug associations must be identified. However, existing models to identify microbe-drug association are limited. In our article, a predictive model (WPCMF) is presented for identifying microbe-drug associations based on weighted profile and collaborative matrix factorization. In WPCMF, the Gaussian Interaction … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 4 · 23 Jan 2022 · 5,735 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPredicting Microbe-Drug Association based on Similarity and Semi-Supervised LearningLingzhi Zhu, Jun Wang, Guixiang Li et al.Increasing clinic evidences have showed that microbial communities play important roles in human health and disease. Predicting hidden microbe-drug associations can be helpful in understanding the microbe-drug association mechanisms in clinical treatment, drug discovery, combinations and repositioning. Some computational methods were proposed to predict the associations of microbes and drugs. However, the prediction performance of these methods needs to be … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 1 · 9 Mar 2021 · 7,535 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInteraction of Momordica charantia with Metformin in Diabetic RatsTripathi Poonam, Gupta Prem Prakash, Lal Vijay KumarNow a day’s people use herb or herbal remedies along with their medication in long term treatment of various disease. Concomitant use of herb and drug can interact with each other may cause herb drug interaction. The present study was designed to investigate the possible herb drug interaction between Momordica Chrantia Fruit Juice (MCFJ) and metformin. Metformin was given orally … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 4 Sep 2013 · 10,167 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSEROTONIN SYNDROME MASKED BY CONCOMITANT INGESTION OF ZOLOFT WITH BENZODIAZEPINE IN SUICIDE ATTEMPT IN A YOUNG HEALTHY MALEKelly Schrapp, Walid OmerThis case report discusses the history and management of a schizophrenic patient, a 18-year-old man, who had taken a massive overdose of clonazepam, abilify, depakote, zoloft and seroquel altogether. After discontinuation of these drugs and administration of cyproheptadine with IV fluids, he became hemo-dynamically stable. This case suggests that serotonin syndrome should be recognized promptly and complications need to be … …Current Research in Medicine, Vol. 5, Issue 1 · 30 Apr 2014 · 7,833 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Evaluation of Synergistic Antibacterial Effects in Blended Essential Oil against Gram-Positive and Gram-Negative PathogensMin-Gi Kwon, Jae Kyung KimThe rising emergence of multidrug-resistant bacteria has heightened the search for novel antibiotic agents. Essential Oils (EOs) are complex combinations of volatile organic compounds generated by plants, with many exhibiting significant antimicrobial properties. This study evaluates the antibacterial movement of single and blended EOs against representative gram-positive bacteria Staphylococcus aureus and Methicillin-Resistant S. aureus (MRSA) and gram-negative bacteria Escherichia coli … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 7 Jul 2025 · 5,481 accessesView PDFCite