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Literature ReviewOpen accessPhrase in the titleDevelopment of Azithromycin Resistance in Streptococcus pneumoniae in the Setting of Trachoma Mass Drug Administration: A Systematic ReviewNazia Khan, Barbara Lachana Onen, Robin Hilder, Robin BaileyTrachoma is a blinding eye disease caused by the bacterium Chlamydia trachomatis. The current global elimination of trachoma initiative includes the use of mass drug distribution of azithromycin in areas where the prevalence of follicular trachoma is >10% in children aged 1-9 years. This study aims to investigate the high quality evidence of whether mass drug administration for trachoma causes … …American Journal of Infectious Diseases, Vol. 16, Issue 3 · 24 Jul 2020 · 7,596 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHistorical Changes in Polychlorinated Biphenyls Contaminated SedimentsViet D. Dang, David M. Walters, Cindy M. LeeProblem statement: PCBs contamination continues to pose a health risk to aquatic environments due to their recalcitrance and bioaccumulation. The Sangamo Weston/Twelvemile Creek/Lake Hartwell Superfund Site is an example of such a health risk as a result of PCBs discharged from a former capacitor manufacturing plant. We conducted a study in twelvemile creek (Clemson, SC, USA) to examine the temporal … …American Journal of Environmental Sciences, Vol. 8, Issue 1 · 25 Jan 2012 · 7,077 accessesView PDFCite
Research ArticleOpen accessIn the keywordsReversal of Dexamethasone Depressant Action in Wound Healing by Ficus Benghalensis L. RootsKrishna Murti, Upendra KumarProblem statement: Ficus benghalensis is widely used plant world wide traditionally as well as scientifically. It has a wide uses in various medical ailments. As a part of pharmacological evaluations, we have carried out wound healing activity specially in dexamethasone depressed healing conditions. Approach: Wound healing activity was established by two medels namely incision and excision. Results: The roots of … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Sep 2011 · 7,302 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPopulation of Vibrio Parahaemolyticus (Pathogen) and Bacillus (Beneficial Bacteria) in Penaeus Monodon (Fabricus, 1798) CultureV. Pattukumar, Maloy Kumar Sahu, M. Murugan et al.Problem statement: The present work was attempted to evaluate the probiotic activity of Bacillus spp. in shrimp health management. Approach: Penaeid culture ecosystem as a confined environment with huge inputs always encourages the proliferation of pathogenic bacteria like Vibrios. Results: From the present study and earlier reports it is understood that these pathogens alone or combine with virus especially White … …OnLine Journal of Biological Sciences, Vol. 10, Issue 4 · 31 Dec 2010 · 7,486 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory and Antioxidant Effects of Stachys Japonica Miq. Ethanol Extract on Cyclophosphamide-Induced Immunosuppressed Mice and its Phytochemical CompositionXueping Jiang, Jianglong He, Yanjun Chen, Fang WangStachys japonica Miq. is an edible wild botanical drug and a traditional medicine in China. This study focused on examining the phytochemical profile and antioxidant properties of the ethanol extract of S. japonica Miq (SJEE) in vitro, as well as its immunomodulatory and antioxidant activities in cyclophosphamide (Cy)-induced immunosuppressed mice. The SJEE was analysed by UPLC-HRMS/MS. 36 Polyphenols, including flavonoids, … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 13 Apr 2026 · 1,449 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial ToxicityConnor Dyer, Katlyn Droke, Ugne Zekonyte, Mariana RoscaDeleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 19 Jan 2024 · 8,562 accessesView PDFCite
Review ArticleOpen accessIn the abstractDrug Interactions Pharmacology: A Narrative ReviewLívia Maria Barbosa Neves, Louryanne de Castro Silva, Mônica Thalia Brito de Melo et al.Thesimultaneous prescription of multiple drugs used in therapeutic schemes canresult in drug interactions, with desirable or undesirable effects. Thus, theobjective of this study was to describe the mechanisms involved in clinicallyrelevant drug interactions. This is a narrative review in which studiespublished in PUBMED and the VHL were searched in the following databases:MedLine, Lilacs, and Scielo. The search was performed in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 25 Oct 2022 · 9,157 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Remdesivir with Poor Clinical Outcomes in COVID-19-A Single Center ExperienceRajat Ranka, Arjun, Prasan Kumar Panda et al.The need for an antiviral against COVID-19 prompted clinical trials worldwide and based on initial promising trends, remdesivir was widely used, including in India (compassionate use). Subsequent trials have been conflicting in their results and the utility of the drug has been widely debated. This is a record-based retrospective cohort study in a 1000-bedded government teaching hospital in North India. … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 3 Jun 2022 · 7,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrevalence and Risk Factors of Bovine Fascioliasis in Northeastern PeruClavel Diaz-Quevedo, Hugo Frias et al.Bovine fascioliasis in Peru is highly prevalent in almost all regions; however, there are few studies about its prevalence in the region of Amazonas. This research aimed to determine the prevalence and risk factors associated with fascioliasis from four livestock basins in the Amazonas region. A total of 941 bovine feces samples were analyzed and a prevalence of 52% was … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 3 · 25 Jul 2023 · 5,685 accessesView PDFCite