5 results for “diabetes induction”

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Research ArticleOpen accessIn the keywordsEffect of Verapamil on Serum Level of Salinomycin in Diabetic RatsHossein Najafzadeh, Said Reza Fatemi, Amir AshnaProblem statement: The aim of present study was evaluation function of P-glycoprotein with or without verapamil in normal and diabetic rats; which the function of P-glycoprotein was indirectly evaluated by detection of serum slainomycin concentration with HPLC method. Approach: This study was carried in 4 groups of rats including normal rats which received salinomycin and verapamil together salinomycin; and diabetic … …American Journal of Applied Sciences, Vol. 8, Issue 9 · 1 Aug 2011 · 6,828 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffect of Streptozotocin-Induced Hyperglycemia on the Progression of Hepatocarcinogenesis in RatsChowdhury Mobaswar Hossain, Bhabani Sankar Satapathy, Laboni Mondal et al.Diabetes mellitus and hepatocellular carcinoma both have detrimental impact on health worldwide. Type II diabetes and liver cancer share many causative factors, but biological correlation between the two diseases still remains elusive. The study was aimed to evaluate the effect of induction of diabetes during the development of hepatocarcinogenesis in rats. Rats were divided into four groups namely, normal control, … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 4 Nov 2013 · 7,521 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInfluence of Quercetin on Diabetes-Induced Alteration in CYP3A Activity and Bioavailability of Pioglitazone in RatsSudhir Niranjan Umathe, Pankaj Vinod Dixit, Jignesh Manubhai Vaghasiya, Nishant Sudhir JainProblem statement: Quercetin-a common bioflavonoid, is present in herbal preparations consumed by diabetic patients along with routine anti-diabetic agents. We recently showed that quercetin increases the bioavailability of pioglitazone in non-diabetic rats. Thus, present study investigated whether this pharmacokinetic interaction is also evident in diabetic animals, especially because diabetic subjects have altered gastrointestinal (GI) function and CYP3A activity. Approach: The … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,819 accessesView PDF Cite

Research ArticleOpen accessIn the abstractHormetic Triggers for Intervention in Aging, Disease and TraumaJoan Smith SonnebornHormesis refers to the ability of a chemical or physical agent to condition the physiological state of an organism to tolerate stress with low doses of otherwise harmful agents. Evolutionary evidence shows that the survival and longevity of species hinge on their optimal ability to resist stress challenge. Hormesis is a potent strategy to stimulate latent repair processes to tolerate … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,898 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes MellitusMariam Al-Shamsi, Amr Amin, Ernest AdeghateThe role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kgˉ1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kgˉ1 … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 8,072 accessesView PDF Cite