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12 articles for “conventional drug”
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Research ArticleOpen accessIn the keywordsMolecular Medicine-Prospects and ChallengesC. N. Ramchand, R. Sripathy, N. Somashekara et al.Drug discovery and development is a process that rationally leads to instigation of compound or formulation for the treatment of particular disease/diseased condition by acting on its specific target (s). Most of the drugs identified by conventional drug discovery process were as a result of unsystematic, random and serendipitous approach. Enhancement of knowledge in the field of biotechnology, molecular biology … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 23 Feb 2012 · 7,473 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Drug-Target Interaction Prediction Based on Supervised Probabilistic ClassificationManmohan Singh, Susheel Kumar Tiwari, G. Swapna et al.Bayesian ranking-based drug-target relationship prediction has achieved good results, but it ignores the relationship between drugs of the same target. A new method is proposed for drug-target relationship prediction based on groups by Appling Bayesian. According to the reality that drugs interacting with a specific target have similarities, a grouping strategy was introduced to make these similar drugs interact. A … …Journal of Computer Science, Vol. 19, Issue 10 · 1 Sep 2023 · 5,454 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffective Strains of Beauveria Bassiana and B. Pseudobassiana used Against the Asian Locust (Locusta Migratoria L.) in KazakhstanUlzhalgas T. Zhumataуeva, Bakhytzhan A. Duissembekov, Yerlan Dutbayev et al.The purpose of the study was to perform genetic identification of the strains of fungi of the Beauveria genus and evaluate the effect of abiotic factors on the growth and survival of colonies and the productivity of conidia of these fungi, as well as to determine the biological effectiveness of the semi-preparative form of the drug based on Beauveria bassiana … …OnLine Journal of Biological Sciences, Vol. 22, Issue 4 · 22 Nov 2022 · 5,702 accessesView PDFCite
Clinical ProcedureOpen accessIn the abstractThe Ruggiero-Klinghardt (RK) Protocol for the Diagnosis and Treatment of Chronic Conditions with Particular Focus on Lyme DiseaseDietrich Klinghardt, Marco RuggieroHere we describe the Ruggiero-Klinghardt (RK) Protocol that is based on integration of Autonomic Response Testing (ART) with diagnostic ultrasonography and on application of therapeutic ultrasounds; the latter are used as a provocation tool and as an instrument to optimize drug uptake and utilization in specific areas of the body. This protocol consists of a precise sequence of diagnostic and … …American Journal of Immunology, Vol. 13, Issue 2 · 8 Mar 2017 · 37,244 accessesView PDFCite
Research ArticleOpen accessIn the abstractInteraction of Aqueous Extract of Trigonella Foenum-Graecum Seeds with Glibenclamide in Streptozotocin Induced Diabetic RatsV. K. Lal, P. P. Gupta, P. Tripathi, A. PandeyProblem statement: Interaction between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Herb traditionally used to decrease glucose concentrations in diabetes could theoretically precipitate hypoglycaemia if taken in combination with conventional drugs. Approach: The present study was undertaken to determine the interaction of Glibenclamide, a Sulphonylurea with Trigonella foenum-graecum seed extract, an herbal … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 4 · 31 Dec 2011 · 8,016 accessesView PDFCite
Review ArticleOpen accessIn the abstractJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite
Review ArticleOpen accessIn the abstractDietary Flavonols With Antiviral Efficacy: Safety and Regulatory ConcernsTanisha Parvez, Tanveer Yaqub, Shama Parveen, Mohammad Khalid ParvezGlobally, a variety of pharmacologically-active plant or natural products are commonly consumed as health-protective dietary supplements. These are marketed as crude formulations, isolated metabolites, multi-vitamins, essential amino acids, unsaturated fatty acids and minerals. Of these, pharmacologically-active flavonols like rutin, quercetin, kaempferol, myricetin, isorhamnetin are the most consumed dietary supplements. In addition to their broad-spectrum therapeutic benefits, these are also known … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 19 Apr 2026 · 1,866 accessesView PDFCite
Research ArticleOpen accessIn the abstractDUAL ROLES OF CANCER CELL-EXPRESSED IMMUNOGLOBULINS IN CANCER IMMUNOLOGYGregory Lee, Cheng-Yuan Huang, Suefay Liu et al.While the expression of immunoglobulins and T cell receptors on cancer cells has been well-established for decades, the potential roles and mechanisms of action of these cancerous antigen receptors have not been fully elucidated. A monoclonal antibody designated as RP215, which reacts specifically with the carbohydrate-associated epitope located on the heavy chain region of cancerous immunoglobulins and T cell receptors, … …American Journal of Immunology, Vol. 10, Issue 3 · 2 Oct 2014 · 7,870 accessesView PDFCite
Research ArticleOpen accessIn the abstractDeveloping a System for Antibacterial Treatment of Dental Caries using Culture Based ApproachM. Mishra, S. Ghosh, L. E. Alex et al.Problem statement: Dental caries is a chronic disease worldwide, caused mainly by microbes. The orthograde approaches still remain the only option of treatment. Lack of rapid antibiotic sensitivity determination of the dental pathogen is a rate limiting step in the field of Dental Microbiology. Approach: The culture dependent analysis was used for the study of oral microflora from five healthy … …OnLine Journal of Biological Sciences, Vol. 12, Issue 2 · 18 May 2012 · 9,061 accessesView PDFCite
Review ArticleOpen accessIn the abstractAntihypertensive Effects of Brazilian FruitsAugusto Altoé Puppin, Christiane Mileib Vasconcelos, Mirian de Almeida Silva et al.Cardiovascular disease is a health problem that generates economic and social impacts worldwide and hypertension is a major risk factor for the development of cardiovascular disease. Currently, conventional medicine offers treatments that control and regulate blood pressure through medication, but the traditional medicines of different cultures have used plants and foods to treat and prevent this type of disease for … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 19 Jun 2020 · 7,187 accessesView PDFCite