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12 results for “chemokines”
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Research ArticleOpen accessEvery word in the titleInterplay of Cytokines and Chemokines in the Pathogenesis of Systemic Lupus ErythematosusDilip Shah, Ajay Wanchu, Archana BhatnagarProblem statement: Dysbalance of T-helper-cell (Th) cytokines and chemokines was suggested to contribute to the pathogenesis of Systemic Lupus Erythematosus (SLE). Recent reports suggest the involvement of cytokines and chemokines in the pathogenesis of SLE, but their relationship with each other and particularly in the severity of disease, was not yet understood. We analyzed the interaction between cytokines and chemokines … …American Journal of Immunology, Vol. 7, Issue 3 · 21 Dec 2011 · 8,161 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMethamphetamine Inhibits β-Chemokines and Co-Stimulatory Molecule Expression by Dendritic CellsMadhavan P.N. Nair, Jose W. Rodriguez, Irina M. Borodowsky et al.The US is currently experiencing a serious epidemic of methamphetamine (Meth) use entangled with HIV-1 infection. Blood monocyte derived dendritic cells (DC ) are the first line of defense against HIV-1 infection and are the initial target of HIV-1 in injection drug users. Chemokines are known to be HIV-1 suppressing molecules and are positively associated with non- progression of HIV … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,543 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInduction of the Chemokines CCL3α, CCL3α and CCL5 in Atherosclerotic PatientsAlyaa Mousa, Amani Al-Zaki, Safa Taha, Moiz BakhietChemokines recruit immune cells to inflammatory sites and promote the process of inflammation. The role of these mediators in the disease process in atherosclerosis is not fully studied. The spontaneous mRNA expression and intracellular protein production of the potential inflammatory chemokines CCL3α and CCL3β (macrophage- inflammatory protein-1α and β; CCR3α/β ligand) and CCL5 (regulated upon activation, normal T cell expressed … …American Journal of Immunology, Vol. 3, Issue 2 · 31 Dec 2007 · 6,952 accessesView PDFCite
Review ArticleOpen accessIn the keywordsCOVID-19: A Review of Current Evidence on Phylogenetics and EtiopathogenesisRafiq Shajahan, Naganathan K. PillaiCOVID-19 represents the latest pandemic caused by the SARS-CoV-2 coronavirus. Coronaviruses are RNA viruses that cause a largely viral mediated immune-related syndrome similar to the SARS epidemic. Following metagenomic sequencing, SARS-CoV-2 closely resembles SARS-CoV (79% similarity) and MERS-CoV virus (50% similarity). Despite this, clinical observations have found varying degrees of infectivity and pathogenesis amongst these viruses. Phylogenetic origins of SARS-CoV-2 … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 2 Apr 2021 · 6,764 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInflammatory Cytokine Expression Patterns in Rat Skin Exposed to JP-8 Jet FuelRandle M. Gallucci, Bethany M. MickleOne of the main complaints of personnel exposed to JP-8 jet fuel is irritant dermatitis. The purpose of this investigation is to describe the JP-8 induced inflammatory cytokine response in skin over various periods of exposure. JP-8 jet fuel or acetone control (300 μL) was applied to the denuded skin of rats once a day for up to seven days. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,042 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsFundamental Questions about γδT CellsMoulay Yassine Belghali, Saadia Ba-M’hamed, Mouna Khouchani, Brahim AdmouγδT cells is a minor subgroup of T lymphocytes expressing γδ-T Cell Receptor (TCR), with many subsets, dominated by Vδ2 and Vδ1. γδT cells recognize antigens independently of the context of MHC class I, MHC class II, or CD1 presenting molecules. However, this recognition requires the expression of the transmembrane Butyrophilin proteins by the presenting cells. Their activation is controlled … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 15 Dec 2020 · 6,382 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInduction of a Soluble Anti-HIV-1 factor (s) with IFN-γ, IL-10, and β-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic MixtureJosé W. Rodríguez, Nat O. Pagan, Mar C. Ocasio et al.Partial immune restoration may be obtained with highly active antiretroviral therapy (HAART), but specific anti-HIV-1 immune responses do not appear to improve substantially. We have demonstrated that a soluble factor(s) induced by a mixture of inactivated influenza and bacterial vaccines called polyantigenic immunomodulator (PAI), possesses strong immunoregulatory and anti- HIV-1 activities. In the present study, we show that culture fluids … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,845 accessesView PDFCite
Research ArticleOpen accessIn the abstractPunicalagin Suppresses Mediators Involved in Labor Onset and Progression in vitroCaitlyn Nguyen-Ngo, Jane C Willcox, Martha LappasSpontaneous preterm birth is the leading cause of neonatal morbidity and mortality. Inflammation plays a central role in the activation of myometrial contractions and rupture of fetal membranes associated with spontaneous preterm birth. The pomegranate polyphenol punicalagin is known to possess anti-inflammatory properties. In this study, we aimed to determine the effect of punicalagin on pro-inflammatory and pro-labor mediators in … …American Journal of Immunology, Vol. 17, Issue 1 · 22 Dec 2021 · 7,609 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,737 accessesView PDFCite
Research ArticleOpen accessIn the abstractMelanoma-Associated Suppression of the Dendritic Cell Lines DC2.4 and JawsiiKristian Michael Hargadon, Yonathan Tarekegne Ararso, Osric Anthony Forrest, Chad Mason HarteDendritic cells function as potent regulators of both innate and adaptive immunity to tumors and the regulatory activities of these cells are tightly linked to their maturation and activation status. Despite the critical role played by dendritic cells in the induction of anti-tumor immune responses, the number of dendritic cells that can be isolated from experimental animals is limiting and … …American Journal of Immunology, Vol. 8, Issue 4 · 3 Nov 2012 · 9,559 accessesView PDFCite