8 articles for “cancer pathogenesis”

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Research ArticleOpen accessIn the keywordsRelationship Between Blood Fibrinogen Concentration and Pathological Features of Cancer Patients: A 139-case Clinical StudyDa-Yong Lu, Xue-Liang Chen, Min Huang et al.Angiogenesis and coagulation are among the most consistent host responses to the presence of a malignant tissue. Pathological angiogenesis and coagulation are often occurred in patients with solid tumors, especially in the occurrence of neoplasm metastasis and as targets for anti-metastatic drugs such as antiangiogenesis agents, coagulation-mediated agents and anticancer drugs. Since fibrinogen (Fib) is the most abundant and key … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 4 Sep 2010 · 7,859 accessesView PDF Cite

EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDF Cite

EditorialOpen accessIn the abstractChasing the Fat Demon: Fat Chance, Buddy?David L. Katz, Joachim Storsberg, Christian SchmidtScience is an interesting profession. At times, one could get caught up in his or her own world of thoughts, perception, far away from reality, sometimes referred to as the proverbial ivory tower (Lederberg, 1972). Science for the sake of science is, per se, not without merit, with our fragmented understanding of a given issue providing ample justification for experimentation … …American Journal of Immunology, Vol. 13, Issue 2 · 29 May 2017 · 8,134 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Role of Inflammation in Development and Therapy of Malignant MesotheliomaArti Shukla, Jill MillerMalignant Mesothelioma (MM) is an asbestos related malignancy with a poor prognosis and limited therapeutic approaches. The pathogenesis of MM has been linked to asbestos induced inflammation. Asbestos exposure results in reactive oxygen species generation, infiltration of inflammatory cells and prolonged release of multiple cytokines, oxidants and growth factors. The role of inflammation in MM has led to the evaluation … …Current Research in Medicine, Vol. 3, Issue 2 · 30 Aug 2012 · 7,437 accessesView PDF Cite

Research ArticleOpen accessIn the abstractNutrient and the Mind-Body Axis, in Relation to Omega-3 Fatty Acids and Amino AcidsToru Takahashi, Eri Toda, Ram B. Singh et al.Noncommunicable Diseases (NCDs); obesity, type 2 diabetes mellitus, Cardiovascular Diseases (CVDs) and cancer have become major health problems in both developing and developed countries. Physical inactivity and increased intake of energy rich proinflammatory foods in association with genetic predisposition are common primary risk factors for these problems. Mind-body interactions and mechanisms in relation to hypothalamus neurotransmitters and vagus nerve have … …Current Research in Medicine, Vol. 3, Issue 1 · 17 Feb 2012 · 7,322 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMutations in Tumor suppressor TP53 Gene in Formalin- Fixed, Paraffin Embedded Tissues of Squamous Cell Carcinoma (SCC) of Lung CancerAbbas Mohammadi, Ali Vaziri Gohar, Mohamad Reza ShakibaieThe TP53 gene mutations have been extensively studied in lung cancer and have been used as a means to understand the origin(s) and mechanisms of these mutations in lung cancer development. TP53 gene mutations occur frequently in many human cancers. Analysis of TP53 gene mutations can also provide clues to the etiology of tumor formation. Formalin-fixed, paraffin embedded (FFPE) tissues … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 8,000 accessesView PDF Cite

Review ArticleOpen accessAll words, across the recordUnveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease PathogenesisRaisa Sergeevna Surkova, Anastasia Vladimirovna Poznyak, Dmitry Alexandrovich Kashirskikh et al.In our review, we have compiled existing information regarding the role of endogenous sialidases (neuraminidases) in the initiation and development of various non-infectious processes in humans. Precisely, pathologies of the cardiovascular system, tumor formations, neurological and metabolic disorders, and hereditary diseases. Sialidases appeared to be widely involved in a variety of human pathologies. An increase or decrease in the enzymatic … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 10 Feb 2024 · 4,546 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordSeroprevalence and Co-Infection of Human Papillomavirus (HPV) Genotypes Among HIV PositivesOkoro Nworie, Euslar Onu, Ogbonnaya Ogbu et al.Human Papillomavirus (HPV) infection is now considered a sexually transmitted disease with particular types being highly oncogenic in nature. High-risk HPV virus infection is a cause of nearly all cases of cervical cancer amongst women. This study determined the seroprevalence of HPV type-16 and type-18 among HIV positive. Blood samples were processed using ELISA test kit and PCR technique. ELISA … …American Journal of Infectious Diseases, Vol. 16, Issue 1 · 9 Mar 2020 · 7,094 accessesView PDF Cite