5 results for “barrier membrane”

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Research ArticleOpen accessIn the keywordsComparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitroAroonsri Priprem, Chidchanok Khamlert, Thaned Pongjanyakul et al.Scales of shed king cobra (Ophiophagus hannah) skin from the dorsal portions, (SSS) and human breast epidermis (HE) were used as barrier membranes for comparison in an in vitro drug permeation study of nine active compounds (MW range 150-300 g mol-1, pKa 3-10). Each compound, saturated in a donor solution at pH 4.0 or 5.6, permeated through the barrier membrane, … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,413 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAMINO ACID TRANSPORTERS IN DRUG DISCOVERYMariafrancesca Scalise, Lorena Pochini, Michele Galluccio, Cesare IndiveriAdministered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other districts influencing their delivery and efficacy. Drugs can also be used as inhibitors of transporters involved in human pathology. Drug-transporter interactions are responsible of off-target effects contributing to toxicity. High Throughput Screening technologies increased the potential applications in therapy or in predicting side effects. These strategies will … …Current Research in Drug Discovery, Vol. 1, Issue 1 · 2 Oct 2014 · 7,099 accessesView PDF Cite

Research ArticleOpen accessIn the abstractShed Skin of Ophiophagus hannah: Structural Topography and In Vitro Permeation of Nicotine and PhenolA. Priprem, T. Pongjanyakul, C. Khamlert et al.Scales of the dorsal portions of shed skin of king cobras (Ophiophagus hannah) was used as the barrier membrane for in vitro permeation of nicotine and phenol at toxic or irritable concentration levels. The scales were placed between solutions of nicotine or phenol in a donor solution at pH 5.6 and a receptor solution at pH 7.4. Cumulative amounts of … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 4 · 31 Dec 2007 · 6,735 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAn in vitro Permeation of Phyllanthus amarus Extract Through Human and Shed Snake SkinsAroonsri Priprem, S. Radapong, S. Preeprame et al.An in vitro permeation of a hydroalcoholic extract of Phyllanthus amarus (PaE) was investigated using excised human epidermis and shed king cobra skin as the barrier membranes. Donor and receptor compartments of diffusion cells were pH-controlled to simulate the permeation environment of the human skin. The PaE was analyzed by using normal-phase densitometric TLC detected at λ 280 nm and … …American Journal of Agricultural and Biological Sciences, Vol. 2, Issue 3 · 30 Sep 2007 · 7,787 accessesView PDF Cite

Review ArticleOpen accessAll words, across the recordAstrocytes Store for Memory and CognitionMajid Karimi BaghmalekiIn humans, protoplasmic astrocytes are found with high density in the cortex and hippocampus (both parts responsible for memory and cognition) and each astrocyte is in contact with two million of synapses. Astrocytes are responsible for the synaptogenesis and the removal of synapses, which is the basis of learning and memory. The synaptogenesis increases sevenfold with the addition of astrocytes … …Neuroscience International, Vol. 12, Issue 1 · 21 Apr 2021 · 17,209 accessesView PDF Cite