4 results for “baclofen”

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Research ArticleOpen accessIn the keywordsInteraction of γ Aminobutyric Acid B Receptors and Electromagnetic Field in the Fear ResponseM. Taherianfard, A. Bahaodini, M. Fazeli, S. Karimi HaghighiOne of the most neurotransmission system consistently linked with fear response is GABAergic system. GABA through GABAB receptor can influence fear response. The aim of the present investigation was to examine the effect of IP injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) along with EMF exposure on frequency of fear response. Fifty adult male rats weighing 180-200 g … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 6,691 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsγAminobutyrate B Receptors in Central Amygdaloid and Medial Amygdaloid Nuclei of Amygdala Modulate Aggression in Male RatsMahnaz Taherianfard, Zahed Abdolahi, Hamid Rajaian et al.One neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) in the Central Amygdaloid (CA) and Medial Amygdaloid (MA) nuclei of the amygdala on offensive aggression behavior in the animal model. Sixty six adult male rats weighing … …Neuroscience International, Vol. 3, Issue 1 · 3 Sep 2012 · 7,257 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsEffect of Intrahippocampal γ Aminobutyrate B Receptor on Pain Sensitivity during Estrous CycleMahnaz Taherianfard, Rohollah GhorbaniProblem statement: There is a relationship between sexual hormones and pain sensitivity and also a role for hippocampal GABAB receptor in nociception. Therefore, the aim of the present investigation was to evaluate the effect of intrahippocampal injection of GABAB receptor agonist (baclofen) and GABAB receptor antagonist (CGP35348) on pain sensitivity during the estrous cycle. Approach: Forty eight adult female rats … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Nov 2011 · 7,342 accessesView PDF Cite

Research ArticleOpen accessIn the abstractNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,166 accessesView PDF Cite