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Research ArticleOpen accessIn the keywordsThe Endoribonuclease Domain of IRE1 and its Substrate HAC1 are Structurally Linked Components of the Unfolded Protein Response in FungiLuis David Maldonado-BonillaThe unfolded protein response sustains the folding capacity of the endoplasmic reticulum under conditions that increase the activity of the secretory pathway. In fungi, the unfolded protein response exclusively depends on the kinase/endoribonuclease IRE1, which senses the accumulation of unfolded proteins in the endoplasmic reticulum lumen and catalyzes the committed step in the unconventional splicing of HAC1 mRNA that encodes … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 14 Oct 2020 · 6,541 accessesView PDF Cite

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