Author

Gheorghe Doros

Boston University, United States

2 articles in our journals

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Research ArticleOpen accessATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDF Cite

Research ArticleOpen accessDesign Based on Intra-Class Correlation CoefficientsRobert Lew, Gheorghe DorosProblem statement: Reliability studies are concerned with the study of "consistency" or "repeatability" of measurements. Often times (but not always) the reliability coefficients are Intra-class Correlation Coefficients (ICC). Depending on the design or the conceptual intent of the study there are three types of intra-class correlation coefficients, termed intra-class correlation coefficients Case 1, 2 and 3, for measuring the reliability … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 18,541 accessesView PDF Cite