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12 results for “analgesia”
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Research ArticleOpen accessIn the keywordsThe Effects of W7, a Specific Calmodulin Inhibitor, to the Antinociceptive Effects of Morphine in Adrenalectomized RatsGholamreza Sepehri, Kayvan Yaghoobi, Vahid Sheibani et al.Problem statement: This study was performed to evaluate the effect of W7 (specific calmodulin inhibitor) on morphine induced analgesia in Adrenalectomized (ADX) rats by tail-flick test. Approach: Tolerance to morphine was induced in male Wistar rats by daily injections of morphine (15 mg kg-1, i.p) for 8 days. Adrenalectomy was performed under general anesthesia with intraperitoneal (i.p) injection of ketamine … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,649 accessesView PDFCite
Review ArticleOpen accessIn the keywordsGabapentin in Cattle: A Pharmacology SnapshotCharbel Fadel, Irene Sartini, Mario GiorgiGabapentin (GBP) is an antiepileptic and analgesic drug that is derived from gamma-aminobutyric acid. It is used as an analgesic in multi-modal pain management, as well as an anticonvulsant and anxiolytic, off-label in animals. Particularly, oral GBP prescriptions for cattle are becoming increasingly popular. Since its introduction into cattle farm practices, several types of research on GBP in cattle have … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 3 · 29 Jul 2022 · 7,821 accessesView PDFCite
Research ArticleOpen accessIn the keywordsComparison of the Analgesic Efficacy of Two Medications in Patients Receiving Dental Implants a Randomized Controlled TrialAlexander Saber, Abdel Rahman Kassir, Nada Naaman et al.The aim of this randomized control trial was to compare the analgesic efficacy of two commonly prescribed medications, mefenamic acid (Ponstan™ Forte) and lysine clonixinate (Dorixina®) in patients undergoing dental implant surgery. A total of 130 patients receiving dental implants were randomized into two groups: 75 treated with Mefenamic Acid (MA) and 75 with Lysine Clonixinate (LC). The primary outcome … …Current Research in Dentistry, Vol. 12, Issue 1 · 16 Oct 2021 · 7,835 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAnti-Inflammatory, Analgesic and Antioxidant Activities of Allophylus Cobbe LeavesPreeti Jain, Md. Selim Hossain, Kaniz Fatema et al.Allophylus cobbe L. Raeuschel (Family-Sapindaceae) is a medicinal plant used traditionally for the treatment of various health risks like pain, inflammation, ulcers and wounds in Bangladesh. This study determined the polyphenolic compounds and evaluated the analgesic, anti-inflammatory and antioxidant effects of the ethanol extract of Allophylus cobbe leaves. High Performance Liquid Chromatography (HPLC) analysis was used to determine the polyphenolic … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 27 Jan 2015 · 8,152 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethadone and Dexmedetomidine Combination as Premedicant Agents for Ovariectomy in CatsH. Tayari, I. Vannozzi, G. Breghi, A. BrigantiThe purpose of this study was to assess sedative and analgesic effects produced by the association of methadone and dexmedetomidine, administered intramuscularly as premedication for ovariectomy in cats. Twenty-four healthy cats were enrolled in the study. The values of heart and respiratory rate were recorded as Tbase. Cats received methadone 0.5 mg kg-1 and dexmedetomidine 5 mcg kg-1 IM. Sedation … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 2 · 27 Jun 2015 · 8,400 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Evaluation of the Epidural Dexmedetomidine, Ketamine or Fentanyl in Combination with Bupivacaine in DogsEman M. Nour, Mahmoud Mahmoud Othman, Gamal I.A. Karrouf, Adel E.I. ZaghloulCastration is one of the most common procedure. It is a potential source of mild to moderate pain which is enough to induce inflammatory process, necessitate the incorporation of analgesics. This study was designed to evaluate the effect of epidural bupivacaine alone or in association with fentanyl, ketamine or dexmedetomidine on analgesia for the first 24 h post surgical castration. … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 8 Nov 2013 · 7,188 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuropharmacological Assessment of an Aqueous Bark Extract of Antiaris toxicaria (Pers.) Lesch. (Moraceae) in RodentsPriscilla K. Mante, Donatus W. Adongo, Kennedy K.E. Kukuia et al.Antiaris toxicaria is a plant traditionally used in Ghana for the treatment of various neurological conditions such as epilepsy and pain. This present study therefore seeks to screen for the neuropharmacological activities of the aqueous extract of Antiaris toxicaria (AAE) stem bark. The effect of Antiaris extract on pentobarbital-induced sleeping time, tail immersion test, spontaneous locomotor activity, motor coordination, PTZ-induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 4 · 27 Nov 2012 · 7,794 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vitro Interaction of 5-Hydroxytrptamine with Cytosolic Molybdenum Hydroxylases as a Potential Inhibitor for Initial Rates ActivitiesAbdullah M. Al-Mohizea, Abd El-Galil E. Amr, Mohamed A. Al-OmarProblem statement: The role of 5-HT has been investigated in many behavioral activities. Thus, studies using raphe lesion showed that 5-HT is involved in sleep, general activity levels, habituation, aggression, pain sensitivity and morphine analgesia, avoidance behavior, self-stimulation and water consumption. Approach: The metabolic interaction between serotonin (5- hydroxytrptamine) and indole-3-aldehyde and xanthine via aldehyde oxidase (EC 1.2.3.1) and xanthine … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,026 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Intracerebroventricular Administration of W-7, A Calmodulin Inhibitor, Attenuate the Development of Morphine Tolerance in RatsGholamreza Sepehri, Vahid Sheibani, Afrooz Azarang et al.Problem statement: The present study was performed to determine the effect of Intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the analgesic effect and development of tolerance to antinociceptive effect of acute and chronic morphine administration respectively. Approach: This study was carried out on male wistar rats, weighing 200-250 g. For acute experimental protocol, Morphine was injected intraperitonealy … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,752 accessesView PDFCite