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13 results for “alloxan-induced diabetic rats”
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Research ArticleOpen accessPhrase in the titleAnti-Diabetic Activity of a Fraction from Cissus verticillata and Tyramine, its Main Bioactive Constituent, in Alloxan-Induced Diabetic RatsCleide de Sousa Lino, Thiago de P. Sales, Patrícia B. Gomes et al.Cissus verticillata (syn. C. sycioides, fam. Vitaceae) is a medicinal plant popularly used in Brazil, for the treatment of diabetes mellitus. The anti-diabetic activity of a fraction from leaves of Cissus verticilllata (MSF, methanol soluble fraction), as well as that of tyramine (TYR) were investigated, in the model of alloxan-induced diabetes, in male Wistar rats. The biochemical parameters studied were: … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 8,628 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEffects of Administration of Alpha-Melanocyte Stimulating Hormone (α-MSH) on Some Hematological Values of Alloxan-induced Diabetic RatsKamal M.S. MansiThis study was designed to evaluate the role of alpha- melanocyte stimulating hormone (α-MSH) on heart rate and some hematological values in alloxan induced diabetic rats. 40 male white rats were divided into four experimental groups: control, diabetic, α-MSH-treated and α-MSH-treated diabetic. At the end of the experimental period (3weeks), animals in all four groups were fasted for 12 hrs … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 7,371 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHypoglycemic and Antihyperlipidemic Effect of Four Korean Medicinal Plants in Alloxan Induced Diabetic RatsJi Su Kim, Jung Bong Ju, Chang Won Choi, Sei Chang KimTo consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extracts from four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba, Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats were administered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used as a diabetic control. Effect of extracts from … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 9,168 accessesView PDFCite
Research ArticleOpen accessIn the abstractExploration of Antidiabetic and Hypolipidemic Activity of Roots of Croton ZambesicusPrakash Kumar, Rahul Kumar, Manoj Kumar Rastogi, Krishna MurtiThe aim of this study was to investigate the potential antidiabetic and hypolipidaemic effects of aqueous and ethanolic extracts of roots of Croton zambesicus in alloxan induced diabetic models to ascertain its pharmacological applicability. The roots of Croton zambesicus were collected, dried and extracted. The phytochemical screening as well as Median Lethal Dose determination (LD50) was done. The ethanolic extract … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 1 · 12 Jun 2017 · 7,856 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Galactomannan Extracted from Iraqi Lycium barbarum L. Fruits against Alloxan-Induced Diabetes in RatsAdnan J.M. Al-FartosyLycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 15 Dec 2014 · 7,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractPeriodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and FansidarE. O. Jimmy, M. A. OkonProblem statement: The antidiabetic potentials of aqueous extract of musa paradisciaca (unripe plantain fruit) were investigated in alloxan induced diabetic rats. The extract at a dosage of 120 mg kg-1 produced a significant (p<0.001) reduction in glucose level by 85% on day 7, 78% on day 14, 64% on day 21 and 44% on day 28. Approach: The extract at … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 22 Mar 2012 · 7,998 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Citrullus colocynthis Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic StudyMohammad Khalil, Gamal Mohamed, Mohammad Dallak et al.Problem statement: The goal of the current investigation was to clarify the effects of Citrullus colocynthis pulp extract on the structure of the liver of diabetic rats at both light and scanning electron microscopic levels. Approach: Forty-eight adult male albino rats were equally allocated into four groups: Group1: control, Group 2: Citrullus colocynthis-treated, Group 3: diabetic rats and Group4: diabetic … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 9,484 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vivo, Acute, Normo-hypoglycemic, Antihyperglycemic, Insulinotropic Actions of Orally Administered Ethanol Extract of Citrullus colocynthis (L.) Schrab PulpMahmoud Al-Khateeb, Mohammad Dallak, Fahaid Al-Hashem et al.Problem statement: Citrullus colocynthis (L.) Schrab (cucurbitaceae family) (Handal) is a fruit commonly known as bitter apple or bitter cucumber. Traditionally, Citrullus colocynthis has been used for the treatment of diabetes. In particular, the acute effect and rout of administration of ethanol extract of the seedless pulp in vivo remains untested. We investigated the effect of different routs of administration … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 8,316 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of Quercetin on Diabetes-Induced Alteration in CYP3A Activity and Bioavailability of Pioglitazone in RatsSudhir Niranjan Umathe, Pankaj Vinod Dixit, Jignesh Manubhai Vaghasiya, Nishant Sudhir JainProblem statement: Quercetin-a common bioflavonoid, is present in herbal preparations consumed by diabetic patients along with routine anti-diabetic agents. We recently showed that quercetin increases the bioavailability of pioglitazone in non-diabetic rats. Thus, present study investigated whether this pharmacokinetic interaction is also evident in diabetic animals, especially because diabetic subjects have altered gastrointestinal (GI) function and CYP3A activity. Approach: The … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,819 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Enicostemma littorale Blume on Rat Model of Diabetic NeuropathyNiraj Mukundray Bhatt, Suparna Barua, Sarita GuptaProblem statement: Poor glycemic control and oxidative stress is implicated as a common pathway in the development of diabetic neuropathy. Approach: In the present study, we investigated the protective effects of Enicostemma littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: Tail flick latency in hot immersion … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,841 accessesView PDFCite