Research ArticleOpen accessIn the keywordsStructural and Evolutionary Analysis of PARPs in D. discoideumA. Mehadvi Kawal, Hina A. Mir, Chethan Kumar Ramniklal et al.Problem statement: Dictyostelium discoideum, a unicellular eukaryote, exhibits multicellularity upon nutrient starvation, making it a better model for developmental studies and for the study of various signal transduction pathways. The most felicitous point of interest is that many of its genes show high degree of similarity to vertebrate genes. Poly (ADP-ribose) polymerase (PARP), a ubiquitous and abundant nuclear protein, has … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,852 accessesView PDFCite
Research ArticleOpen accessIn the abstractTRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES-AMAZING TOOL FOR GENOME EDITINGAvantika Singh, Vivek Pratap SinghTranscription Activator-Like Effector Nucleases (TALENs) are used to cut specific target DNA sequence in order to knock out a gene or to change its sequence. They are formed by the fusion of TALE protein serving as DNA binding domain along with non-specific DNA cleaving nucleases. Its specificity towards DNA bases in the target sequence is derived from the structure of … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 7,997 accessesView PDFCite