Research ArticleOpen accessIn the keywordsA Bayesian Method for Disentangling Dependent Structure of Epistatic InteractionJing Zhang, Qu Zhang, Darrin Lewis, Michael Q. ZhangProblem statement: We propose a Bayesian method (RBP) to recursively infer the independence structure of epistatic interactions in case-control study. Approach: Based on the results of BEAM2, RBP can powerfully detect the marginal and conditional independence within interacting SNPs even in the complicated interaction cases. Results: We did extensive simulations to test RBP and compare it with stepwise logistic regression. … …Current Research in Biostatistics, Vol. 2, Issue 1 · 13 Jan 2012 · 7,481 accessesView PDFCite
Research ArticleOpen accessIn the abstractBayesian Determination of Disease Associated Differences in Haplotype BlocksIvan Kozyryev, Jing ZhangProblem statement: While experimental ascertainment of haplotype blocks in the genome-scale case-control studies is expensive, accurate computational phasing is still a daunting task for bioinformatics approaches. We used a statistical method to determine differences, potentially associated with a certain disease, in linkage disequilibrium block boundaries in whole-genome Single Nucleotide Polymorphisms (SNPs) data. Approach: We utilized a Bayesian model for calculating … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 14 Feb 2012 · 8,428 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordInsulin Pump Therapy in Type 1 Diabetes-Merging Technology with Diabetes CareH. ThabitThe use of insulin pump therapy has been increasing over the past number of years in many countries. The Diabetes Control and Complications Trial (DCCT) have proven that better glycaemic control with fewer hypoglycemic events is achievable with insulin pump therapy. The delivery of subcutaneous insulin through an insulin pump mimics physiological insulin delivery better than Multiple Daily Injection of … …Current Research in Medicine, Vol. 3, Issue 2 · 22 May 2012 · 7,208 accessesView PDFCite