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44 articles for “Toxin”
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Literature ReviewOpen accessEvery word in the titleThe Anti-Nociceptive/Anti-Inflammatory Actions of Botulinum Toxin A for the Treatment of Chronic Pain: A Literature ReviewRacha Hajj, Camille HaddadThe aim of this article is to describe the new actions of botulinum toxin A for chronic pain treatment. BT/A inhibits the exocytosis of synaptic vesicles containing the pain mediators neurotransmitters, reduces the post traumatic trigeminal neuralgia pain, inhibits the release of microglia derived TNF-α as well as other pro inflammatory cytokines, viable treatment option in the case of patients … …Current Research in Dentistry, Vol. 12, Issue 1 · 10 Aug 2021 · 7,772 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLetter: The Idea of Using Botulinum Toxin to Treat Anxiety DisordersTaleb Al AbdulmohsenAfter botulinum toxin was shown to help treat depression, I asked whether it can be therapeutic for anxiety disorders as well. In this brief letter, I go beyond pointing out my pioneering role in the suggesting of this idea and into highlighting some intuitive and counterintuitive aspects of this topic and some misconceptions. For example, if it is true that … …Current Research in Medicine, Vol. 4, Issue 1 · 7 May 2013 · 6,911 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleT-2 Toxin Regulated Ganoderma lucidum Induced Cytokine ReleaseKazem Ahmadi, Majid RiazipourThe water-soluble extract of Ganoderma lucidum (Reishi) has been used as immunomodulator to stimulate spleen cells proliferation and cytokine expression. It has also been shown that at some level of exposure, T-2 toxin typically act as immunosuppressive agent and can increase disease susceptibility. The aim of this study was to investigate the effect of T-2 toxin on cytokine production by … …American Journal of Immunology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,538 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of pH on the Conformation and Biological Activity of Clostridium septicum Alpha-toxin, a Pore-forming HemolysinB.M. Hang'ombe, T. Kohda, M. Mukamoto, S. KozakiThe effects of pH on the pore-forming Clostridium septicum alpha-toxin that causes myonecrosis was assessed at pH 5.0, 7.0 and 9.0 by measuring circular dichroism and its biological activity. Incubation of the toxin at pH 5.0 increased the hemolytic activity measured in murine red blood cells. On the other hand, incubation of the toxin at pH 9.0 drastically reduces the … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Jun 2007 · 6,902 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBotulinum Toxin as a Novel Addition to Anti-Arthritis ArmamentariumHamid Namazi, Zahra MajdOsteoarthritis is the most common joint disease and is among the most frequent health problems for middle aged and older people. There is strong evidence that proinflammatory cytokines contribute to cartilage degradation in osteoarthritis. Interleukin-1 is the prototypical proinflammatory cytokine implicated in the pathogenesis of cartilage matrix degeneration. Results from studies in animal models provide stronger evidence implicating a role … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,775 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffects of Purified Tick Saliva Toxins on Various Bio-Molecules in Blood Serum, Liver and Muscles of Albino MiceNidhi Yadav, Ravi Kant UpadhyayIn the present study, salivary toxins from Rhipicephalus microplus were isolated and purified on a Sepharose CL 6B 200 gel column at a constant flow rate with regular fractions of 5 mL/min. Pooled fractions were lyophilized and LD50 was then determined in albino mice. The LD50 value of the protein toxin of Rhipicephalus microplus was found 36.11 mg/kg body weight … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 1 · 30 Dec 2023 · 5,354 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInhibition of Panton-Valentine Leukocidin Toxin Induced Neutrophil Cell Lysis by Vancoplus in Methicillin-Resistant Staphylococcus Aureus InfectionsManu Chaudhary, Santosh Kumar Patnaik, Anurag PayasiPantone Valentine Leukocidin (PVL) is a cytotoxin associated with virulence of Methicillin-Resistant Staphylococcus aureus (MRSA). This study was undertaken to analyze the prevalence of PVL among MRSA strains and to study the effect of adjuvants (L-lysine, L-arginine, Ethylenediamine Tetraacetic Acid (EDTA) as well as drugs on PVL induced neutrophil cell lysis. Further, in vitro activity of Vancoplus, vancomycin, linezolid, teicoplanin … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 20 Dec 2014 · 7,106 accessesView PDFCite
InvestigationOpen accessEvery word in the titleEffects of Recombinant Toxin Phospholipase D in Cardiac Muscle of RatsJoao Victor Capelli Peixoto, Fernando Augusto Lavezzo Dias, Carlos Estevan Nolf Damiani et al.Loxoceles spiders gender are worldwide spread and its bites can cause dermonecrosis or even a systemic effect (hemolysis, kidney and liver injury). It is believed that phospholipase D, the main component present in the venom, could be responsible for the injury. In this study, we used a recombinant form of phospholipase D (rLiD1) and evaluated its direct and systemic effects … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 2 Jun 2015 · 6,956 accessesView PDFCite
InvestigationOpen accessIn the keywordsThe Effect of Adding Zeolite in the Feed of Chickens Cobb 500Angel Roberto Sánchez Quinche, Faviola Margarita Pindo Nagua, Oliverio Napoleón Vargas González et al.The objective of this study was to evaluate the effects of the addition of zeolite on the feeding of Cobb 500 chickens in the productive parameters. The work was carried out in an integral farm of Ecuador, adopting the standards of biosafety and animal welfare for the breeding of poultry; no vaccines or drugs were administered. 200 chickens (1-day old) … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 3 · 25 Sep 2017 · 8,661 accessesView PDFCite
Research ArticleOpen accessIn the keywordsStudy of pH and Cellular Response in Pulmonary Fibroblasts After Exposure to Market Street World Trade Center Particulate MatterMichelle Hernandez, Sung Choi, Ann Marie DiLorenzoChronic health conditions have been noted among first responders and residents exposed to the dust generated from the World Trade Center (WTC) collapse on September 11, 2001. This study sought to isolate a single factor thought to play a substantial role in the decreased lung function of World Trade Center (WTC) workers and victims. Human pulmonary fibroblasts were exposed to … …OnLine Journal of Biological Sciences, Vol. 12, Issue 4 · 8 Feb 2013 · 7,322 accessesView PDFCite