Research ArticleOpen accessPhrase in the titleDevelopment of Cell-Responsive Nanophase Hydroxyapatite for Tissue EngineeringR. Murugan, S. RamakrishnaScaffold plays a critical role in engineering bone tissues by providing necessary structural support for the cells to accommodate and guiding their growth in the three dimensional (3D) space. Therefore, designing scaffold that mimic composition and structural aspects of the bone is of great importance to promote cell adhesion, cell-matrix interactions, osteointegration, tissue formation and continued function. Nanophase hydroxyapatite (HA) … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 7,163 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleComposite Scaffolds for Bone Tissue EngineeringMin WangBiomaterial and scaffold development underpins the advancement of tissue engineering. Traditional scaffolds based on biodegradable polymers such as poly(lactic acid) and poly(lactic acid-co-glycolic acid) are weak and non-osteoconductive. For bone tissue engineering, polymer-based composite scaffolds containing bioceramics such as hydroxyapatite can be produced and used. The bioceramics can be either incorporated in the scaffolds as a dispersed secondary phase or … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,355 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleGene Technology in Tissue EngineeringXiao-Dan Sun, In-Seop LeeScaffold, cells and signaling factors are regarded as the three essential components in tissue engineering. With the development of molecular and cell biology, gene technology is beginning to show a promising position in tissue engineering as it can influence these essential components at DNA-level. By introducing plasmid DNA or genes encoding certain signaling factors (growth factors/cytokines) into the cells, required … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,401 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleBioceramics for Tissue Engineering Applications-A ReviewSunho Oh, Namsik Oh, Mark Appleford, Joo L. OngThree dimensional (3-D) scaffolds have been explored in an attempt to persuade the body to heal or repair tissues that do not do so spontaneously. Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. However, the material and 3-D scaffolds ideal for optimal regeneration of missing or lost tissues has not been identified. While current … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 10,420 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleTissue Engineering of Articular Cartilage: A Mini-ReviewRadoslav Zamborsky, Jana Rusnakova, Andreas NicodemouDamage of articular cartilage due to congenital anomaly, injury or pathological process may lead in decreasing of life quality of affected patients. In many cases, conventional therapeutical approaches may not bring expected results. Tissue engineering by the combination of material technology and cell-based therapy may represent hope for these patients. The main goal of this review article is to summarize … …OnLine Journal of Biological Sciences, Vol. 14, Issue 4 · 5 Jan 2015 · 6,925 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleInduced Microcracking Affects Osteoblast Attachment on Hydroxyapatite Scaffolds for Tissue EngineeringIan O. Smith, Melissa J. Baumann, Eldon D. CaseBone microdamage caused by routine activity plays an important role in triggering targeted and nontargeted bone remodeling. Targeted remodeling occurs near localized areas of microdamage[1-4]. We hypothesize that bone remodeling may be directly and positively influenced by inducing microcracks in hydroxyapatite (HA) scaffolds for bone tissue engineering. A study by Case et al. showed microcracking in HA discs having >98% … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,557 accessesView PDFCite
Research ArticleOpen accessIn the keywords3D Printing of Porous Scaffolds for Medical ApplicationsAblah Aljohani, Salil DesaiCustom engineered scaffolds that mimic the physiology of native tissue is an emerging need for successful regenerative medicine. One of the key challenges in current manufacturing methods is the lack of controlled porosity throughout the scaffold structure. In this research, our group explores the fabrication of tissue engineering scaffolds using 3D printing technology. The fused deposition modeling method was utilized … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 3 · 19 Jun 2018 · 8,508 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGrowth of Bone Marrow Derived Osteoblast-Like Cells into Coral Implant Scaffold: Preliminary Study on Malaysian CoralK. A. AL-SalihiProblem statement: Biomaterial fabrication in Malaysia started as a consequence of the demand for cheaper implant materials. Various biomaterials have been developed utilizing local resources like Malaysian coral. Locally processed Malaysian coral need to be complemented with proper evaluation and testing including toxicology, biocompatibility, mechanical properties, physicochemical characterization and in vivo testing. The present study was carried out to assess … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 6,590 accessesView PDFCite
Research ArticleOpen accessIn the keywordsNanoceramic Matrices: Biomedical ApplicationsWilli Paul, Chandra P. SharmaNatural bone consisted of calcium phosphate with nanometer-sized needle-like crystals of approximately 5-20 nm width by 60 nm length. Synthetic calcium phosphates and Bioglass are biocompatible and bioactive as they bond to bone and enhance bone tissue formation. This property is attributed to their similarity with the mineral phase of natural bone except its constituent particle size. Calcium phosphate ceramics … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,361 accessesView PDFCite