InvestigationOpen accessIn the keywordsChronic Lyme Disease: A Working Case DefinitionRaphael B. Stricker, Melissa C. FeslerAlthough Lyme disease is the most common tickborne illness in the USA and Eurasia, the pathophysiology and clinical course of chronic Lyme disease (CLD) have not been formally defined. The purpose of this paper is to present a working case definition of CLD based on analysis of more than 700 peer-reviewed publications. According to this definition, CLD is a multisystem … …American Journal of Infectious Diseases, Vol. 14, Issue 1 · 16 Apr 2018 · 21,285 accessesView PDFCite