Research ArticleOpen accessIn the keywordsA Phenolic Ester of O-Desmethylvenlafaxine (ODV) Improves Uptake of ODV into the BrainYang Zhang, Zhichao Yang, Sen Zhao, Hongli ZhouIn this study, the in vitro stabilities of a promising O-Desmethylvenlafaxine (ODV) phenolic ester prodrug O-19 in aqueous solution, rat whole blood and rat liver microsomes were investigated. In addition, the in vivo drug metabolites were determined using LC-TOFMS-IDA-MS/MS. O-19 exhibits high stabilities at any pH encountered in the gastrointestinal tract, its half live (t1/2) spans the range 5.0±0.18 d … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 11 Dec 2016 · 7,157 accessesView PDFCite
Research ArticleOpen accessIn the abstractDiscovery of an Equilibrium Circle in the Circular Restricted Three Body ProblemFawzy A. Abd El-SalamProblem statement: A traial to find equilibrium points in out of plane of the restricted three body problem. Approach: Solution of the equations of motion at equilibrium points. Linearizing the equations of motion and computing the eigen values to investigate the stability. Results: New triangular equilibrium points in plane perpendicular to the plane of motion and passing through Lagrange triangular … …American Journal of Applied Sciences, Vol. 9, Issue 9 · 16 Jul 2012 · 7,362 accessesView PDFCite
Research ArticleOpen accessIn the abstractChelation Study of Captopril with Cd2+ and Pb2+ IonsMohammad Joshaghani, M.B. Gholivand, A.R. MosavatThe protonation constants of Captopril, (1-(3-mercapto-2-(S)-methyl-1-oxopropyl)-S(L) proline, (CPL) and stabilities of its two divalent metal ions Cd(II) and Pb(II) were determined potentiometrically in two different metal to ligand ratio 1:1 and 1:2 systems and in water and methanol-water binary mixtures using the computer Best program. Two protonation constants were obtained which were assigned to the carboxylic and thiol groups. All … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 30 Sep 2008 · 6,923 accessesView PDFCite
Research ArticleOpen accessIn the abstractApplication of RNA-DNA Duplex Base Triplets to Antisense DrugsJie Yang, Yao Leng, Ju BaoSixty-four sets of three-dimensional models of RNA-DNA duplex base triplets were constructed based on codons by homology modeling method using software InsightII on Indigo workstation, which should be helpful for the study of RNA-DNA annealing, the basis of nucleic acids interactions and some peculiar motifs for design antisense oligonucleotides. Our research result reveal that the energies (such as E, Ec, … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,531 accessesView PDFCite
Research ArticleOpen accessIn the abstractConformational Analysis of Trans-3, 6-Dibutanal-1, 2, 4, 5-TetroxaneEduardo A. Castro, Mariela I. Profeta, Jorge M. Romero et al.We report the results of theoretical semiempirical AM1 and PM3 molecular orbital methods on the conformational analysis of the title compound. The relative stability of different isomers and conformers are discussed on the basis of well defined electronic and steric effects, which are rather helpful in order to understand the relative stabilities. …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,695 accessesView PDFCite