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131 results for “Specificity”
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Research ArticleOpen accessEvery word in the titleA Novel Industrially Promising Keratinase Isolated from Aspergillus aureolatus Changes its Substrate Specificity after pH-Mediated AutolysisArina Mokhova, Anna ShestakovaMicrobial proteolytic enzymes are green catalysts with many potential applications. Keratinolytic enzymes (or keratinases) are crucial for efficient keratin degradation, making them essential in waste management, biomedicine, cosmetics, and various industrial applications. This study describes the production and characterization of a protease with keratinolytic activity from Aspergillus aureolatus. The protease was isolated from the culture fluid on the 5th day … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 1 · 14 Feb 2025 · 5,580 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleStage Specificity of Eurycomanone Isolated from Eurycoma longifolia on Plasmodium falciparum CyclesEti Nurwening Sholikhah, Mahardika Agus Wijayanti, Ratna Asmah Susidarti et al.Eurycomanone is the most active compounds in the roots of Eurycoma longifolia and shown to have in vitro antiplasmodial activity. However, the stage of Plasmodium falciparum cycles which are sensitive to eurycomanone have not been investigated. This study was conducted to investigate stage specificity of eurycomanone at various stages of P. falciparum life cycles. Stage specificity of eurycomanone at various … …American Journal of Pharmacology and Toxicology, Vol. 11, Issue 1 · 16 Jan 2016 · 7,739 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProbing the Substrate Specificity and Intersubunit Interactions of Brevundimonas Diminuta Glutaryl Acylase with Site-Directed MutagenesisMichael Eldarov, Anna Lyashenko, Tatyana Sherbakova et al.Glutaryl-7-ACA acylases (GLA) are industrial enzymes widely used for the production of 7-aminocepahlosporanic acid (7-ACA)-the starting compound for manufacturing of semisynthetic cephalosporin antibiotics. Generation of mutant GLA's with increased activity and stability, capability for single-step conversion of cephalosporin C (CPC) directly to 7-ACA is a promising route to improve the current biocatalytic technologies. In this study GLA from Brevundimonas diminuta … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 12 Nov 2014 · 8,160 accessesView PDFCite
Research ArticleOpen accessIn the keywordsFine-Tuned and Optimized Transformer-Based Model for EEG Seizure DetectionPuspanjali Mallik, Ajit Kumar Nayak, Kumar Janardan Patra et al.Epilepsy, a widely recognized neurological disorder, results from irregularities in the transmission of electrical impulses among neurons in the brain. Over the last two decades, significant efforts have been made by researchers and clinicians to develop effective methods for its early detection and management. The electroencephalogram (EEG), a non-invasive tool used to monitor brainwave activity, has become a central device … …Journal of Computer Science, Vol. 21, Issue 11 · 11 Feb 2026 · 1,412 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRecognition of Pathological Voices by Human Factor Cepstral Coefficients (HFCC)Rabeh Hamdi, Salah Hajji, Adnene CherifHuman speech is a means of communication that is very important in our daily lives. It is characterized by its great ability to transmit our ideas, our emotions, our personality etc. So, any alteration of the voice can prevent the person from exercising his professional and daily life naturally. It is for these reasons that it is very necessary to … …Journal of Computer Science, Vol. 16, Issue 8 · 7 Aug 2020 · 6,859 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAn Extended Semi-Parametric Accelerated Failure Time Cure Model for Partial Cure Information KnownYu Wu, Yong Lin, Shou-En Lu et al.Cure model is a useful model for analyzing failure time data when there is evidence of long-term survivors. In traditional cure models, it is assumed that the cured or uncured status in the censored set cannot be distinguished. However, in many occasions, data of some diagnostic procedures, with some sensitivity and specificity, may have provided partial information about the cured … …Current Research in Biostatistics, Vol. 8, Issue 1 · 11 Dec 2018 · 7,618 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCombination of Serological Tests (Anti-CCP Antibody, Rheumatoid Factor IgM ELISA and Latex Test) are more Useful in Detection of Rheumatoid ArthritisAnindya Das, Chimanjita Phukan, Chitralekha BaruahRheumatoid arthritis is a polyarticular and chronic inflammatory disease occurring throughout the world. To prevent significant joint damage, early diagnosis and proper treatment is of paramount importance. Though patients are diagnosed clinically supported by radiography and serological tests, early disease may present with non-specific arthritis and absence of specific radiographic findings. Though anti-CCP antibody is used for the diagnosis and … …American Journal of Immunology, Vol. 13, Issue 3 · 23 Sep 2017 · 7,389 accessesView PDFCite
Research NotesOpen accessIn the keywordsFunctionalization Strategies for Antibodies: Lessons LearnedChristian Schmidt, Martin Geyer, Jörg Bohrisch et al.Precious little is known about useful functionalization strategies of antibodies that will not impair either reactivity or specificity of this valuable reagent. We used an experimental approach to demonstrate our own experience with published protocols. The conjugates obtained were then tested with regard to their performance against commercially available detection kits. Our results are then viewed in light of published … …American Journal of Immunology, Vol. 13, Issue 2 · 4 May 2017 · 7,592 accessesView PDFCite
Research ArticleOpen accessIn the keywordsNeuronal Functions of Protein Phosphatase 2AHung-Tat Leung, Ning WangReversible protein phosphorylation is a common and important form of protein posttranslational modification which determines the proteins’ activities, substrate specificity and inhibitions or degradations, depending on the specific amino acid residue, or combination of residues, being targeted. While protein phosphorylations by kinases have been well studied, the importance of protein dephosphorylation by phosphatases has emerged over the past two decades … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 7,777 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPROCALCITONIN AS A MARKER FOR EARLY DIAGNOSIS OF SEPSISRahim Raoofi, Zahra Salmani, Fatemh Moradi et al.Sepsis is a critical condition often caused by bacterial infection and associated with death and mortality. The prognosis of this disease depends on early diagnosis and proper treatment. Definite diagnosis of sepsis is positive blood culture and this test needs a long time to perform, so other biochemical parameters such as procalcitonin serum level has been introduced. To determine sensitivity, … …American Journal of Infectious Diseases, Vol. 10, Issue 1 · 23 Dec 2013 · 7,476 accessesView PDFCite