3 articles for “Sildenafil”

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Research ArticleOpen accessEvery word in the titleSildenafil in the Treatment of Postoperative Hypoxemia with High Resistance in Cyanotic Congenital Heart DiseaseZhou Jiawang, Lv Yong, Hu Zhendong et al.This study was designed to determine the effect of sildenafil treatment on postoperative hypoxemia with high resistance in cyanotic congenital heart disease. A total of 247 cases of cyanotic congenital heart disease were operated on from May 2006 to August 2014. Only 45 cases exhibited postoperative hypoxemia after symptomatic treatment. Sildenafil at doses of 0.30-5 mg/kg every 6 h was … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 3 · 1 Sep 2017 · 7,682 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleUtility of Certain Π Acceptors for Spectrophotometric Determination of Sildenafil CitrateNora H. Al-ShaalanSildenafil citrate was determined through charge transfer complexes (CTC) formation with three electron acceptor reagents. The methods involve the reaction of Sildenafil citrate as n-donor with either Chloranil (tetrachloro 1,4-benzoquinone), tetracyanoethylene (TCNE) or 7,7,8,8-tetracyanoquinodimethane (TCNQ) as n-acceptors, to give a stable and highly colored radical anion. The colored products were quantified spectrophotometrically. The condition ranges adhering to Beer's law are … …American Journal of Applied Sciences, Vol. 4, Issue 10 · 31 Oct 2007 · 7,387 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsCardiac Depression Produced by L-Arginine and Phosphodiestrase Inhibitor on Isolated Mammalian Rabbit Heart: Function of Cyclic Guanosine Monophosphate (cGMP)Hussein F. Sakr, Fahaid Al-Hashem, Mahmoud Al-Khateeb et al.Problem statement: Cyclic guanosine 3',5'-monophosphate cGMP is one the important second messengers that determines the cardiomyocyte activity and its role in healthy and diseased cardiac muscle is still controversial. We are reporting the effect of adding L-arginine, the NO donor that stimulates cGMP production and Sildenafil citrate (phosphodiestrase inhibitor) that inhibits cGMP hydrolyis on isolated rabbit’s heart to answer: Is … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,182 accessesView PDF Cite