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45 articles for “Signaling Pathway”
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Research ArticleOpen accessPhrase in the titleRole of the Wnt/β-Catenin Signaling Pathway in Reducing Lipogenesis of Obese Rats Under Hypoxic ExercisePeiming Xu, Zhiyuan Sun, Xiaoyi Tian et al.Hypoxic exercise exerts a significant effect on body weight loss and body fat reduction. Methods: In the present study, we constructed an obese rat model and divided rats into the following groups: Normoxic quiet (C), Hypoxic quiet (H), Normoxic Exercise (CE), and Hypoxic Exercise (HE). We employed isobaric tags for relative and absolute quantification (iTRAQ) using proteomic technology to screen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 2 · 3 Jun 2022 · 5,737 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleSignaling Pathways Involved In Dengue-2 Virus Infection Induced RANTES OverexpressionYing-Ray Lee, Huan-Yao Lei, Shun-Hua Chen et al.Dengue viruses participate in liver inflammation by inducting the expression of various chemokines including Regulated on Activation Normal T-cell Expressed and Secreted (RANTES). However, the underlying signaling remains unknown. Here, we reveal that Ras, Raf-1 and three mitogen-activated protein kinases (MAPKs) p38, extracellular signal-regulated kinase (Erk), and c-jun-NH2-terminal kinase (JNK) can be activated or phosphorylated in dengue-2 virus infected hepatocyte … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,173 accessesView PDFCite
EditorialOpen accessPhrase in the titleFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and ImmunologyBruno R.B. Pires, Andre L. Mencalha, Gerson M. Ferreira et al.Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the subunits HIF-1α and HIF-1β. The … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,482 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCrosstalk between Oxidative Stress Signaling and HER2 Pathway in Breast CancerVanessa Jacob Victorino, Adriano Martin Felis Aranome, Fernanda Carolina de Campos et al.About 20% of breast cancer patients overexpress the Human Epidermal growth factor Receptor-2 (HER2), also known as ErbB2. HER2-overexpression is associated with enhanced tumor malignancy and its overexpression is related to specific target therapy against breast tumors and other cancers. HER2-mediated pathways in tumor cells act on behalf of the tumor conferring aggressive characteristics. Several reports demonstrated the occurrence of … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,038 accessesView PDFCite
Review ArticleOpen accessIn the keywordsStrigolactones in Plant Stress Adaptation: Mechanisms and Agricultural PotentialHumayra Ferdus, Mahabuba Mostafa, Md. Motaher HossainAbiotic stresses have significant negative effects on the growth, development, and productivity of crop plants, which are critical to global agricultural production and ecosystem stability. Strigolactones (SLs), a family of carotenoid-derived plant phytohormones, have been identified as playing key roles in plant development and adaptive responses to environmental stimuli. Initially recognized as signaling molecules in host-parasite interactions and as symbiotic … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 3 Oct 2026 · 559 accessesView PDFCite
Research ArticleOpen accessIn the keywordsFabrication of Polysaccharides from a Fermented Tea and Their Antioxidant and Hypoglycemic ViabilityJun Li, Lingxian Tong, Bing Li et al.The hypoglycemic effects of tea have been extensively studied, with fermented tea demonstrating notable efficacy owing to its distinct processing methods. This study involved the extraction of tea polysaccharides from Wuniuzao Black Tea (WTP) using a water extraction and ethanol precipitation method. WTP-1 and WTP-2 were obtained by separation and purification using DEAE-52 cellulose columns. Antioxidant activity was evaluated utilizing … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 30 Jul 2026 · 655 accessesView PDFCite
Research ArticleOpen accessIn the keywordsUPLC-QTOF-MS/MS and Bioinformatics Association Analysis Reveals the Pharmacodynamic Flavonoids in Scutellaria barbata and the Underlying Anti-Colorectal Cancer MechanismYi-Jie Cheng, Xin-Yun Du et al.Colorectal Cancer (CRC) is one of the most common and deadly malignancies worldwide, with no safe and effective drugs. The flavonoid in Scutellaria Barbata D. Don (SB) showed a good therapeutic effect on CRC. However, the pharmacodynamic substances and underlying mechanisms have not been elucidated which limited its development and application. This study aimed to identify the main flavonoid in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 14 Nov 2023 · 5,398 accessesView PDFCite
Review ArticleOpen accessIn the keywordsMicroRNA-92a: The Administrator of Certain DiseasesZhiyuan Sun, Qing Xu, Xiaoyi Tian et al.MicroRNA-92a (miR-92a) is an evolutionarily conserved noncoding small RNA that can regulate gene expression after transcription. Previous studies have found that miR-92a is overexpressed in many tumors and can regulate numerous tumor suppressor genes negatively, with relevant effects on the development of different tumors, by regulating the DUSP10/c-Jun N-terminal kinase (JNK), phosphatase and tensin homologs (PTEN)/AKT, Wnt and EP4/Notch1 signaling … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 21 May 2020 · 6,494 accessesView PDFCite
Review ArticleOpen accessIn the abstractJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite