6 articles for “Resistant Mutants”

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Research ArticleOpen accessPhrase in the titleDetection of Hepatitis C Virus Resistant Mutants in the era of Direct Acting AntiviralsLivia Maria Gonçalves Rossi, Paula RahalHepatitis C Virus (HCV) infects millions of people and represents an important public health problem in different regions of the world. Drug resistance is a major challenge for HCV-infection related control. Importantly, the arrival of a plethora of novel, more powerful drugs has revolutionized the field of HCV treatment. Here, we discuss the relevance of identification of HCV resistant mutants … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 6,429 accessesView PDF Cite

Review ArticleOpen accessIn the abstractThe HCV Replicase InteractomeAntonio Mas, Pilar Clemente-Casares, Eugenio Ramírez, Rosario SabariegosViruses are obligate parasites and can only reproduce within host cells because they lack metabolic pathways to complete their replication cycles. Host factors required in viral replication are mainly those involved in lipid metabolism, cell cycle control and apoptosis, cell-to-cell interactions, immune system regulation, etc. Several inhibitors targeting viral polymerases have been designed. However, the rapid appearance of resistant mutants, … …Current Research in Virology, Vol. 5, Issue 1 · 27 Jul 2016 · 13,210 accessesView PDF Cite

Research ArticleOpen accessIn the abstractChemical Mutagenesis for Improvement of Production of a Biologically Active Extracellular Polymeric Substance by Halomonas xianhensis SUR308Jhuma Biswas, Amal K. PaulA moderately halophilic bacterium, Halomonas xianhensis SUR308 (Genbank Accession No. KJ933394) isolated from solar saltern of Surala, Odisha, India was found to produce significant amount of a biologically active extracellular polymeric substances (EPS). Under optimized cultural conditions, the strain was able to produce 7.05 g L-1 of EPS after 8 days of incubation under shake culture. To enhance the EPS … …Current Research in Microbiology, Vol. 7, Issue 1 · 1 Apr 2016 · 15,918 accessesView PDF Cite

Research ArticleOpen accessIn the abstractINHIBITORY ACTIVITY OF POTENTOX AGAINST DNA GYRASE OF ENTEROBACTERIACEAEManu Chaudhary, Anurag PayasiDNA gyrase, a type II topoisomerase catalyzes the supercoiling of relaxed closed circular DNA. In this report we evaluated the in vitro inhibitory effect of non antibiotic adjuvant compounds disodium edetate and sodium citrate against supercoiling activity of bacterial DNA gyrase. Further, we assessed the effect of different drugs alone and in combination with one or more adjuvants in overcoming … …American Journal of Infectious Diseases, Vol. 10, Issue 1 · 8 Feb 2014 · 7,288 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAnalysis of Resistance to Human Immunodeficiency Virus Protease Inhibitors Using Molecular Mechanics and Machine Learning StrategiesA. Harishchander, D. Alex Anand, Sanjib SenapatiProblem statement: Drug resistance is the most important factor, which influences the failure of current HIV therapies. So, the ability to predict the drug resistance of HIV-1 protease mutants will be useful in developing more effective and longer lasting treatment regimens. Approach: Drug resistance of HIV-1 protease is predicted with two current protease inhibitors (Indinavir and Saquinavir). The problem was … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,204 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordEthanol Production by Novel Proline Accumulating Pichia kudriavzevii Mutants Strains Tolerant to High Temperature and Ethanol StressesRika Indri Astuti, Sena Alifianti, Ratu Nabila Maisyitoh et al.Accumulation of osmoprotectant molecule, proline, has been reported to induce a stress tolerance phenotype in yeast cells. In this study, two ethanologenic isolates of yeast, Pichia kudriavzevii (R and T), both capable of using both five and six sugar compounds to produce ethanol, were mutated via ethyl methanesulfonate (EMS) treatment. Prolineaccumulating mutant strains were selected by using proline-analogue (L-azetidine-2-carboxylic acid). … …OnLine Journal of Biological Sciences, Vol. 18, Issue 3 · 11 Sep 2018 · 7,838 accessesView PDF Cite