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Research ArticleOpen accessIn the keywordsCholesterol Metabolism in Brain and Skin Fibroblasts from Sarda Breed Sheep With Scrapie-resistant and Scrapie-susceptible GenotypesAlessandra Pani, Claudia Abete, Claudia Norfo et al.Scrapie is a fatal spongiform encephalopathy of sheep, a transmissible form of prion disease caused by neuronal accumulation of the aberrantly conformed prion protein (PrPsc). Currently, no ante-mortem diagnostic tests are available to detect this untreatable disease in the pre-clinical stage, thus making difficult to control its spread. Recent evidence suggests that the production of PrPsc can be modulated by … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,257 accessesView PDFCite