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15 results for “Protein Secretion”
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Research ArticleOpen accessEvery word in the titleAmphetamine Stimulates Protein Kinase and Calcium Influx to Increase Corticosterone and Aldosterone Secretion from Male Rat Adrenal CellsLing-Ling Chang, Wan-Song Alfred Wun, Cai-Yun Jian, Paulus S. WangAmphetamine is a potent central nervous system stimulant. Clinical trials have demonstrated that in healthy adults, low (therapeutic) doses of amphetamine can improve i.e., cognition, memory, attention behavior. An amphetamine overdose can affect cardiovascular, central nervous system, musculoskeletal, respiratory, urinary, or sexual function. Furthermore, amphetamine can activate the hypothalamic-pituitary-adrenal axis to increase glucocorticoids and mineralocorticoids released from adrenal. The object … …American Journal of Pharmacology and Toxicology, Vol. 16, Issue 1 · 10 Mar 2021 · 7,872 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Use of α-MF Signal Peptide Without Spacer for Producing Insulin Aspart Precursor in Pichia pastoris KM71Popi Asri Kurniatin, Fifi Fitriyah Masduki, Neni Nurainy et al.A spacer peptide (Glu-Ala repeats) connects N-terminal of a polypeptide precursor to the signal peptide of α-mating factor (α-MF) from Saccharomyces cerevisiae. During the polypeptide precursor secretion, the signal peptide will be first cleaved by signal peptidase in the endoplasmic reticulum, followed by Kex2 endopeptidase and finally the spacer peptide is removed by dipeptidyl aminopeptidase in the Golgi apparatus. In … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 4 · 31 Oct 2019 · 9,026 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Atorvastatin on Oxidized Low-Density Lipoprotein-induced Proliferation, Apoptosis, and Matrix Metalloproteinase-9 Expression in Human MacrophagesBensheng Liu, Huifan Li, Yan Wang, Li ZhangAtorvastatin (ATV), an HMG-CoA reductase inhibitor, is utilized in the treatment of atherosclerotic diseases. Mononuclear Macrophages (MMs) are critical immune cells involved in atherosclerosis progression, participating in processes such as foam cell formation, cytokine secretion, and the development of fibrous cap and lipid core. To further elucidate the mechanism by which ATV exerts its therapeutic effects on atherosclerosis through the … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 18 Nov 2025 · 2,133 accessesView PDFCite
Case ReportOpen accessIn the abstractBrief Report: 20-Year Follow-Up of an Infant with Neurological Impairment Born to a Mother with Variant Creutzfeldt-Jakob DiseaseJustin Penner, Anjali Rampersad, James E. Burns et al.A term infant born via uncomplicated caesarian section was noted to be jittery, hypotonic, and have pooling of secretions at birth. Over the first four weeks of life, the infant developed four limb hypertonia, hyperreflexia, and clonus. MRI at 3.5 weeks old showed brain immaturity, poor myelination, and increased signal in the dorsal thalami. At six months, dystonic features with … …American Journal of Infectious Diseases, Vol. 21, Issue 1 · 7 Mar 2025 · 7,660 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvolvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5)Anwar M Hasan, Gordon DentEosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines. The intracellular mechanisms that control the activation, recruitment and survival of eosinophils are fundamental in understanding these disease processes. Phosphoinositide 3-kinase (PI3K) has been shown previously to … …American Journal of Immunology, Vol. 13, Issue 4 · 26 Oct 2017 · 7,943 accessesView PDFCite
Research ArticleOpen accessIn the abstractNutritional and Fatty Acids Profile Analyses of Commonly Consumed Fresh Water Fish Species in PakistanAhsan Hameed, Syed Ammar Hussain, Muhammed Asim Shabbir et al.The aim of this study is to evaluate nutritional value of selected commonly consumed fresh water fish species of Pakistan. Proximate composition and fatty acids profile of mostly consumed fresh water fish species of Pakistan namely Balm or Baam (Anguilla anguilla), Sole (Channa marulius), Damra (Labeo rohita) and Malhi (Wallago atto) were analysed. Proximate composition data showed a significant difference … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 1 · 31 Jan 2017 · 9,515 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of a Mushroom (Coriolus versicolor) Based Probiotic on Goat HealthKingsley Ekwemalor, Emmanuel Asiamah, Sarah Adjei-Fremah, Mulumebet WorkuMaintenance of an adequate immune response is essential to goat health. CorPet biomass is a mushroom (Coriolus versicolor) based probiotic used as an immune-stimulant in man, horses and small animals. Fifteen BoerXSpanish goats were used in a crossover design to evaluate the effect of a commercial mushroom based probiotic across two periods on resilience of goats to gastrointestinal parasites in … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 3 · 4 Oct 2016 · 7,923 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdiponectin Regulation in Type 2 Diabetic Rats: Effects of Insulin, Metformin and DexamethasoneTamer Ahmed Ismail, Mohamed Mohamed Soliman, Shimaa Ahmed IsmailAdiponectin is a protein synthesized from adipose tissue, increases peripheral glucose utilization in liver and skeletal muscle. Adiponectin expression and secretion are decreased during obesity and insulin resistance. In this study, the effect of insulin, metformin and dexamethasone on serum lipid profiles was examined in Type 2 Diabetic (T2D) rats. T2D was induced by feeding rats a high fat diet … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 23 Nov 2013 · 7,723 accessesView PDFCite
Research ArticleOpen accessIn the abstractRegulation of Retinol Binding Protein 4 Expression and its Relation to Adipogenesis in Bovine AdipocytesMabrouk Ragab EL-Sabagh, Abd Eldaim Mabrouk AttiaAdipogenesis is of great importance in beef cattle. Recent findings indicate that glucose, a substrate for fatty acid biosynthesis and retinoic acid enhance adipogenesis in bovine intramuscular adipocytes. However, other recent findings indicate that Retinol-Binding Protein 4 (RBP4) interferes with glucose uptake and utilization by rodents’ adipocytes. In this study we examined the regulation of RBP4 expression and its relation … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 3 · 20 Sep 2012 · 8,399 accessesView PDFCite
Research ArticleOpen accessIn the abstractHigh Incidence of Disorder-Promoting Amino Acids in the Amino Terminus of Mature Proteins in Bacillus subtilisGuangqiang Wang, Yining Dong, Haiqin Chen et al.Problem statement: Exported polypeptides are usually synthesized as preproteins which are composed with mature domains and the signal peptides. The foreign proteins are usually inefficiently secreted by the aid of signal peptides. Although we know that the mature protein played an important role in the protein export process, we do not know what properties of the mature domains are critical … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 2 Feb 2012 · 8,255 accessesView PDFCite