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Research ArticleOpen accessIn the keywordsChelation Study of Captopril with Cd2+ and Pb2+ IonsMohammad Joshaghani, M.B. Gholivand, A.R. MosavatThe protonation constants of Captopril, (1-(3-mercapto-2-(S)-methyl-1-oxopropyl)-S(L) proline, (CPL) and stabilities of its two divalent metal ions Cd(II) and Pb(II) were determined potentiometrically in two different metal to ligand ratio 1:1 and 1:2 systems and in water and methanol-water binary mixtures using the computer Best program. Two protonation constants were obtained which were assigned to the carboxylic and thiol groups. All … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 30 Sep 2008 · 6,923 accessesView PDFCite