Research ArticleOpen accessEvery word in the titleReverse Pharmacology-A Paradigm Shift for Drug Discovery and DevelopmentAshok D.B. VaidyaThe current scenario of drug discovery and development is facing a model perturbation, despite significant advances in genomics, proteomics, metabolomics, combinatorial chemistry and high through put assays. There is an urgent need of a paradigm shift in approaches to drug discovery. Natural products of Ayurveda offer a vast potential for novel phytomolecules with clinical activity. In India, Ayurveda is availed … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 15,398 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProblem-Based Clinical Cases Increase the Level of Pharmacology Education for Physiotherapy StudentsYazun Bashir JarrarProblem statement: Pharmacology course is mandatory course for physiotherapy students in most of Middle Eastern Universities. Most of physiotherapy students believe that they should not study pharmacology course during bachelor degree. In addition, their marks in pharmacology course were lower than other medical basic courses. Approach: The present study investigated how to improve the level of pharmacology education for physiotherapy … …Current Research in Medicine, Vol. 2, Issue 1 · 29 Mar 2011 · 10,112 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleDrug Interactions Pharmacology: A Narrative ReviewLívia Maria Barbosa Neves, Louryanne de Castro Silva, Mônica Thalia Brito de Melo et al.Thesimultaneous prescription of multiple drugs used in therapeutic schemes canresult in drug interactions, with desirable or undesirable effects. Thus, theobjective of this study was to describe the mechanisms involved in clinicallyrelevant drug interactions. This is a narrative review in which studiespublished in PUBMED and the VHL were searched in the following databases:MedLine, Lilacs, and Scielo. The search was performed in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 25 Oct 2022 · 9,157 accessesView PDFCite
EditorialOpen accessEvery word in the titleImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleGabapentin in Cattle: A Pharmacology SnapshotCharbel Fadel, Irene Sartini, Mario GiorgiGabapentin (GBP) is an antiepileptic and analgesic drug that is derived from gamma-aminobutyric acid. It is used as an analgesic in multi-modal pain management, as well as an anticonvulsant and anxiolytic, off-label in animals. Particularly, oral GBP prescriptions for cattle are becoming increasingly popular. Since its introduction into cattle farm practices, several types of research on GBP in cattle have … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 3 · 29 Jul 2022 · 7,821 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHormesis: Principles and Applications for Pharmacology and ToxicologyEdward J. CalabreseThe present assessment places hormetic dose responses within an historical context, documenting its origin, rejection by the biomedical community during the early decades of the 20th due to its close association with homeopathy and its revitalization during the later decades of the past century as the biomedical and toxicological communities became very interested in low dose effects of drugs and … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,210 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Combined Phytohemagglutinin And α-Ketoglutarate Pharmacology Study of Gut Morphology and Growth in Older Adult RatsR. Filip, A. Harrison, S. G. PierzynowskiThis study has evaluated the effect of phytohaemagglutinin (PHA) in combination with alpha-ketoglutaric acid (AKG), on GI-tract morphology and N balance in adult rats. Rats, aged approx. 15 months, were assigned to one of four experimental groups, (1) Control group, (2) AKG group, (3) AKG+PHA 100% group and (4) AKG+PHA 1% group. AKG and AKG+PHA were administered via a stomach … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,082 accessesView PDFCite