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6 results for “PTZ”
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Research ArticleOpen accessIn the keywordsAnticonvulsant Effect of Pitavastatin in Mice Induced by PentylenetetrazoleKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipid-lowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,507 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: The Cyclooxygenases (COXs), the key enzymes that convert arachidonic acid to Prostaglandins (PGs), had been implicated in physiological and pathophysiological functions in the CNS. Non-Stesoidal Anti-Inflammatory Drugs (NSAIDs), COX inhibitors, were used largely to treat febrile condition, pain state and for prevention of and therapeutics of many diseases. However the role of PGs and NSAIDs in the seizure … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 13 Dec 2011 · 7,675 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSynthesis and Calcium Channel Blocking Activity of 1, 4-Dihydropyridine Derivatives Containing Ester Substitute and Phenyl Carbamoyl GroupBassem Sadek, Khairi Mustafa Salem Fahelelbom, Laurentiu Morusciag, Sigurd ElzProblem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester with an amide (5-phenylcarbamoyl) moiety has been reported. Approach: Six new derivatives of m-nifedipine have been successfully synthesized by substituting an ester moiety with an amide … …American Journal of Applied Sciences, Vol. 8, Issue 4 · 18 Apr 2011 · 8,247 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in MiceSameh Mohamed Mostafa EL-Nabtity, Ahmed Shaban Abdelaziz, Manar Salah Moselhi, Mario GiorgiEpilepsy is a group of long-term neurological disorders characterized by epileptic seizures. The present study sought to investigate the anticonvulsant and neuroprotective Activity of Hydroalcoholic Phoenix dactylifera fruit extract (HAPD) and Pimpinella Anisum Oil (PAO) against Pentylenetetrazole (PTZ) and Maximal Electric Shock (MES) induced a seizure in mice. Mice groups were treated with HAPD1000 mg/kg, PAO 4 ml/kg. The onset … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 2 · 25 May 2019 · 7,590 accessesView PDFCite
Research ArticleOpen accessIn the abstractANTICONVULSANT AND NEUROTOXICITY EVALUATION OF SOME NEWLY SYNTHESIZED THIAZOLYL COUMARIN DERIVATIVESM. Faiz Arshad, Nadeem Siddiqui, Ahmed Elkerdasy et al.The present series of compounds were synthesized with the aim to develop newer anticonvulsant agents that are comparatively more efficacious and safer than the currently used anticonvulsant agents. Various thiazolyl coumarins were synthesized by the reaction of 3-(bromoacetyl)-2H-chromen-2-one with different substituted aryl thiourea. The structures of the synthesized compounds were confirmed by spectral data and elemental analyses. Compounds were tested … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 26 Mar 2014 · 7,676 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuropharmacological Assessment of an Aqueous Bark Extract of Antiaris toxicaria (Pers.) Lesch. (Moraceae) in RodentsPriscilla K. Mante, Donatus W. Adongo, Kennedy K.E. Kukuia et al.Antiaris toxicaria is a plant traditionally used in Ghana for the treatment of various neurological conditions such as epilepsy and pain. This present study therefore seeks to screen for the neuropharmacological activities of the aqueous extract of Antiaris toxicaria (AAE) stem bark. The effect of Antiaris extract on pentobarbital-induced sleeping time, tail immersion test, spontaneous locomotor activity, motor coordination, PTZ-induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 4 · 27 Nov 2012 · 7,794 accessesView PDFCite