Research ArticleOpen accessEvery word in the titleA Phenolic Ester of O-Desmethylvenlafaxine (ODV) Improves Uptake of ODV into the BrainYang Zhang, Zhichao Yang, Sen Zhao, Hongli ZhouIn this study, the in vitro stabilities of a promising O-Desmethylvenlafaxine (ODV) phenolic ester prodrug O-19 in aqueous solution, rat whole blood and rat liver microsomes were investigated. In addition, the in vivo drug metabolites were determined using LC-TOFMS-IDA-MS/MS. O-19 exhibits high stabilities at any pH encountered in the gastrointestinal tract, its half live (t1/2) spans the range 5.0±0.18 d … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 11 Dec 2016 · 7,157 accessesView PDFCite