8 results for “Nitric Oxide Synthase”

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Research ArticleOpen accessPhrase in the titleProgressive LDL Reduction to Very Low Levels Improves Dimeric Nitric Oxide Synthase, Nitric Oxide Bioavailability and Reduces Peroxynitrite in Endothelial Cells during HyperglycemiaR. Preston Mason, Hazem Dawoud, Samuel C.R. Sherratt et al.Circulating levels of glucose and LDL influence Endothelial Cell (EC) function in a highly interactive manner as evidenced by nitric oxide production and coupling of endothelial Nitric Oxide Synthase (eNOS) dimer. Here, we report on the status of eNOS function in Human Umbilical Vein Endothelial Cells (HUVECs) cultured under normo- and hyperglycemic (250 mg/dL) condition followed by exposure to increasing … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 2 May 2019 · 8,356 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titlePalmitate-Induced Translocation of Caveolin-3 and Endothelial Nitric Oxide Synthase in CardiomyocytesCatherine J. Knowles, Megan Dionne, Martina Cebova, Ilka M. PinzProblem statement: Palmitate is a known cardiac lipotoxin that blunts cardiomyocyte contractile function and induces apoptosis, likely via accumulation of the lipotoxic ceramide. Ceramide is a sphingolipid and localizes to caveolae, which are lined in the inner membrane leaflet by caveolin proteins. In this study, we investigated the effects of palmitate on caveolin proteins and on endothelial Nitric Oxide Synthase … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 27 Aug 2011 · 7,894 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleImpact of L-Carnitine and Cinnamon on Insulin-Like Growth Factor-1 and Inducible Nitric Oxide Synthase Gene Expression in Heart and Brain of Insulin Resistant RatsMona A. MohamedProblem statement: Evaluate the effects of daily administration of L-carnitine and cinnamon extract for two weeks on the expression of Insulin-like Growth Factor-1 (IGF-1) and inducible Nitric Oxide Synthase (iNOS) genes in cardiac and brain tissues of rats with Insulin Resistance (IR). Approach: Rats were divided into 4 groups (8 animals each): Group (1) rats fed control diet (60% starch) … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 8,740 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleAmelioration of Inducible Nitric Oxide Synthase, Insulin like Growth Factor-1 Gene Expression and Insulin Receptor Substrate-1 in Liver Tissue of Insulin Resistant Rats Treated With L-CarnitineHala M. GhanemProblem statement: It has been reported that genes expression (inducible Nitric Oxide (iNOS). Insulin-like Growth Factor-1(IGF-1) have a role in both glucose homeostasis and insulin resistance. The aim of this study was designed to evaluate the amelioration of the iNOS, IGF-1 genes expression as well as IRS-1 in liver tissues of rats fed high fructose diet treated with Lcarnitine. Approach: … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,264 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsIncreased Production of Nitric Oxide Contributes to Renal Oxidative Stress in Endotoxemic RatBahar Tunçtan, Belma Korkmaz, Hatice Yıldırım et al.Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotoxic shock. Nitric oxide (NO) produced by inducible NO synthase (iNOS) during endotoxemia is the major cause of vascular hyporeactivity, hypotension and multiple organ failure. In this study, we investigated whether increased production … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 8,638 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsSitagliptin Impairs Healing of Experimentally Induced Gastric Ulcers Via inhibition of iNOS and COX-2 ExpressionAmina Unis, Eman AbdelzaherGastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was conducted on … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 4 Sep 2013 · 7,436 accessesView PDF Cite

Research ArticleOpen accessIn the abstractREMEDIAL EFFECTS OF VITAMIN E AND L-ARGININE ON PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN-INDUCED DIABETIC RATSIsmaeel Bin-Jaliah, Samah El-Attar, Eman F. Khaleel et al.It was shown that hyperglycemia in diabetic patients is the main factor of diabetic peripheral neuropathies. Various pathways related to oxidative stress, vascular defect and defective endothelium dependent relaxation have been implicated in the development of diabetic peripheral neuropathy. A substantial number of studies have shown that antioxidant treatment are promising therapeutics that can prevent or correct reduced motor nerve … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 23 Dec 2013 · 8,041 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDihydrobiopterin (BH2): Key Determinant in Influencing Arginine Mediated Endothelial Tolerance and DysfunctionSrinidi Mohan, Harsh Patel, Jorge Bolinaga et al.The redox-sensitive tetrahydrobiopterin (BH4) is an essential cofactor that is required by endothelial Nitric Oxide Synthase (eNOS) for L-arginine (ARG) mediated Nitric Oxide (NO) generation. Oxidation of BH4 causes cofactor insufficiency and uncoupling of eNOS, resulting in product switching from NO to O2⋅– production. Here we tested the hypothesis that eNOS uncoupling is not simply a consequence of BH4 insufficiency, … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 8,348 accessesView PDF Cite