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41 results for “Multidrug-resistance”
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Research ArticleOpen accessEvery word in the titleP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffectiveness of Disinfectants on Environmental Multidrug Resistance Contaminants Causing Skin Abscess in Farm AnimalsSultan Farag Nagati, Soumaya S. A. El Shafii, Shaimaa R. A. Abd El MawgoudResistance to antimicrobial agents is recognized as a growing problem for different farms and infection of farm animals with abscesses is detrimental to livestock due to the enormous economic losses. This study aimed to find out the bacterial infection of some cases in farm animals suffering from wounds and abscesses in Fayoum Governorate, Egypt and Related Antimicrobial Resistance (AMR) procedures … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 3 · 11 Aug 2021 · 7,193 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntibacterial Activity of Marine Source Extracts Against Multidrug Resistance OrganismsNagi A. AL-Haj, Nurmas I. Mashan, Mariana N. Shamsudin et al.Problem statement: Antimicrobial resistance is the major problem of global dimensions with a significant impact on morbidity, mortality and healthcare-associated costs. The problem has recently been worsened by the steady increase in multiresistant strains and by the restriction of antibiotic discovery and development programs. Methicillin-resistant Staphylococcus aureus, pseudomonads and Escherichia coli are a major nosocomial and community-acquired pathogens for which … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 10,073 accessesView PDFCite
Review ArticleOpen accessIn the keywordsMultidrug Resistant Microorganisms (MDR) and Biofilm Producers: A Challenge for Hospital Infectious ControlDaniel Lucio, Elizabeth Proaño, Alberto Bustillos et al.Antimicrobial Resistance (AMR) now represents a major threat to contemporary health care, especially in hospitals, where repeated antimicrobial exposure selects for and facilitates the dissemination of Multidrug-Resistant (MDR) microorganisms. Biofilm growth adds another layer of persistence by increasing microbial tolerance, supporting long-term colonization of medical devices, and worsening clinical and economic outcomes. This narrative review synthesizes evidence on MDR biofilm-forming … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 12 Sep 2026 · 774 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPrevalence and Antibiotic Sensitivity test of Salmonella Serovars from Enteric Fever Suspected Patients Visiting Alka Hospital, LalitpurKalpana Pandey, Vijay K. Sharma, Roshani MaharjanEnteric fever is still an important public health problem in developing countries including Nepal. A changing antibiotic susceptibility pattern of Salmonella Typhi and Salmonella Paratyphi A has increased to a great concern. To determine the prevalence and antibiotic sensitivity pattern of S. enteric serovars Typhi and Paratyphi from blood specimen in enteric fever suspected culture positive cases. A cross-sectional study … …Current Research in Microbiology, Vol. 6, Issue 2 · 30 Oct 2015 · 7,952 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Effect of Phyllanthus taxodiifolius Beille Extracts and its Triterpenoids Studying on Cellular Energetic Stage of Cancer CellsPatiwat Sakkrom, Wilart Pompimon, Puttinan Meepowpan et al.Problem statement: The Multidrug Resistance phenomenon (MDR) is the cause of unsuccessful in cancer chemotherapy. The tradition plant is the population used as the alternative medicine in cancer therapy. Due to, P. taxodiifolius is medicinal Thai plant which is used as diuretic drug which has never been explored as the anticancer activities. Approach: Air-dried powder of P. taxodiifolius leaves and … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 8,750 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDetection of Methicillin-Resistant Staphylococci (MRS) and Salmonella spp. in Consumer Egg SamplesAna Claudia Lemes Pavan, Rafaella da Silva, Vanessa Kelly Capoia Vignoto et al.Despite the excellent nutritional value, the egg can be an important vehicle for bacterial infections carried by food, among them, multiresistant Staphylococci and salmonellosis. The objective of this work was to detect the presence of Methicillin-Resistant Staphylococcus spp. (MRS) and Salmonella spp. Forty dozen eggs were obtained from three free-trade fairs in the Umuarama-PR; every dozen eggs comprised a sample. … …American Journal of Animal and Veterinary Sciences, Vol. 15, Issue 3 · 21 Aug 2020 · 6,529 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGenetic Mutation Assessment of NPM1 Gene and Gene Expression of MDR1 in Iraqi Patients with Acute Myeloid LeukemiaAhmed Abduljabbar Suleiman, Ali Zaid Al-Saffar, Tamadher Abbas Rafaa, Hasan Abdulwahab JwadSince its discovery, mutations in NPM1 have been frequently associated with a large number of Acute Myeloid Leukemia (AML) patients. The vast majority of genetic changes were previously detected in exon 12, however little information report mutations in Nuclear Export Signal region (NES) of NPM1. Sequencing analysis included exon 2 and 3 for 75 Iraqi AML patients showed three SNPs, … …OnLine Journal of Biological Sciences, Vol. 18, Issue 1 · 11 Jan 2018 · 7,782 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDrug Susceptibility Pattern of M.Tuberculosis Isolated from Patients Attending a Private HospitalD. Sureshkumar, Ram GopalakrishnanProblem statement: Drug resistance in Tuberculosis (TB) is an emerging problem that adversely affects patient outcome and public health in the developing world. Although much of tuberculosis care is provided by the private sector in India, the magnitude of drug resistance in TB in the private sector is not well described. The present study was carried out to determine the … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 22 Dec 2011 · 7,281 accessesView PDFCite
Research ArticleOpen accessIn the keywordsQuercetin, Quercetrin Except Rutin Potentially Increased Pirarubicin Cytotoxicity by Non-Competitively Inhibiting the P-Glycoprotein-and MRP1 Function in Living K562/adr and GLC4/adr CellsWinit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan et al.Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combination with other agents, this study aims to analyze the interaction of the compounds with the MDR transporters including … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 9,670 accessesView PDFCite