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20 results for “Multidrug Resistance (MDR)”
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Research ArticleOpen accessIn the keywordsP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDFCite
Research ArticleOpen accessIn the keywordsQuercetin, Quercetrin Except Rutin Potentially Increased Pirarubicin Cytotoxicity by Non-Competitively Inhibiting the P-Glycoprotein-and MRP1 Function in Living K562/adr and GLC4/adr CellsWinit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan et al.Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combination with other agents, this study aims to analyze the interaction of the compounds with the MDR transporters including … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 9,670 accessesView PDFCite
Review ArticleOpen accessIn the abstractMultidrug Resistant Microorganisms (MDR) and Biofilm Producers: A Challenge for Hospital Infectious ControlDaniel Lucio, Elizabeth Proaño, Alberto Bustillos et al.Antimicrobial Resistance (AMR) now represents a major threat to contemporary health care, especially in hospitals, where repeated antimicrobial exposure selects for and facilitates the dissemination of Multidrug-Resistant (MDR) microorganisms. Biofilm growth adds another layer of persistence by increasing microbial tolerance, supporting long-term colonization of medical devices, and worsening clinical and economic outcomes. This narrative review synthesizes evidence on MDR biofilm-forming … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 12 Sep 2026 · 774 accessesView PDFCite
Review ArticleOpen accessIn the abstractMechanistic Insights of Actions of Metal Nanoparticles on Multidrug-Resistant BacteriaSeham S. Alzahrani, Hani Mohammed Ali, Mohamed M. AhmedMultidrug-Resistant bacteria (MDR) are the most serious threat to public health. The number of infections caused by resistant strains is on the rise all over the world. At this time, new techniques for developing antimicrobial drugs are becoming necessary. Metallic Nanoparticles (MNPs) in the biomedical field are one of the most promising methods to overcome antibiotic resistance. Nanoparticles have recently … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 22 Jun 2021 · 6,374 accessesView PDFCite
Research ArticleOpen accessIn the abstractDominant Multidrug-Resistant Bacteria in Five Biggest Hospitals in Asir Region from March to June 2018Mohammed AlmaghrabiThere is a rapid increase in the emergence of multidrug resistance which consider as one of the public health threats in all over the world. MDR was defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories. The present study aims to determine the dominant multi-drug resistant bacteria in the five biggest hospitals in Asir … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 9 Mar 2021 · 6,782 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrevalence and Genotypic Analysis and Antibiotic Resistance of Salmonella Species Isolated from Imported and Freshly Slaughtered ChickenWael K. Elfeil, Mahmoud E. Ezzat, Amira Fathi et al.Salmonellosis is a bacterial disease caused by different types of Salmonella species and associated with clinical disease in both human, birds and livestock species. Salmonellosis associated with severe economic impacts either from losses in poultry farm due to pathological picture losses, cost of medication, condemnation in slaughterhouse or zoonotic important. This study focused on the prevalence of Salmonellae in imported … …American Journal of Animal and Veterinary Sciences, Vol. 15, Issue 2 · 28 May 2020 · 6,986 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenetic Diversity and Drug Resistance of Mycobacterium tuberculosis Complex Isolates and Nontuberculous Mycobacteria Identification from Presumptive Tuberculosis Cases in Oaxaca, MexicoNakamura-Lopez Yuko, Valencia-Carmona Oscar Daniel, Martinez-Cruz Perla Monica et al.Tuberculosis (TB) is a re-emerging health problem worldwide. In Mexico, information about genetic diversity and drug resistance of Mycobacterium Tuberculosis complex (MTBc) is limited. Samples from 463 Presumptive TB cases were tested for TB by smear, culture and PCR, from which 19.2% were identify as MTBc and 16% as nontuberculous mycobacteria. MTBc isolates were characterized by Large Sequence Polymorphisms (LSPs), … …American Journal of Infectious Diseases, Vol. 16, Issue 1 · 9 Feb 2020 · 7,159 accessesView PDFCite
Research ArticleOpen accessIn the abstractMultidrug Resistant Uropathogens among Egyptian Pregnant WomenWafaa Salah Metwally, Walid Mohamed ElnagarUrinary Tract Infections (UTIs) in pregnancy is a common medical problem associated with significant increase in the risk of fetal morbidity and mortality. The effective appropriate antimicrobial agent is a major concern as many effective antimicrobial groups cannot be used due to their potential toxicity to the fetus as well as the increasing rates of Multidrug-Resistant (MDR) strain isolation. This … …American Journal of Infectious Diseases, Vol. 15, Issue 4 · 21 Dec 2019 · 7,487 accessesView PDFCite
Research ArticleOpen accessIn the abstractOccurrence of Antibiotic Resistant C. jejuni and E. coli in Wild Birds, Chickens, Environment and Humans from Orang Asli Villages in Sungai Siput, Perak, MalaysiaIbrahim Mohamed Mohamed-Yousif, Jalila Abu, Saleha Abdul-Aziz et al.In developing countries, Escherichia coli and Campylobacter jejuni were found to be the prominent bacterial causes of gastroenteritis in human gastroenteritis, and they also showed an increased trend towards antibiotic resistance. Thus, the study aimed to determine the occurrence of E. coli and C. jejuni in wild birds, chickens, human and environment in villages in Perak and to determine the … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 3 · 5 Aug 2019 · 8,909 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial Resistance of Campylobacter spp. and Arcobacter butzleri from Pets in MalaysiaMohammed Dauda Goni, Abdinasir Yusuf Osman, Saleha Abdul Aziz et al.The emergence of antimicrobial resistance in pets is not well understood and methods of surveillance are only beginning to be established in a few countries. The consequence of antimicrobial resistant Campylobacter and Arcobacter butzleri to public health is due to the propensity of the bacteria to swiftly acquire and disseminate resistance gene. Thus, making way for the emergence of new … …American Journal of Animal and Veterinary Sciences, Vol. 13, Issue 4 · 29 Nov 2018 · 7,690 accessesView PDFCite