3 results for “Mucosal Vaccines”

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Research ArticleOpen accessPhrase in the titleTargeting Cellular Receptors as a Strategy for the Development of New Generation Mucosal VaccinesConstantine Bitsaktsis, Kari Wiedinger, Edmund Joseph GosselinMucosal pathogens are a primary source of infection that require the development of vaccines to induce a specific, protective and long lasting immune response. Despite an urgent need, development of effective mucosal immunization strategies has proven difficult. The literature was reviewed to elucidate cell specific targets that may be utilized to increase the immunogenicity of protective antigens through mucosal vaccination. … …American Journal of Immunology, Vol. 9, Issue 1 · 2 Feb 2013 · 7,026 accessesView PDF Cite

Review ArticleOpen accessIn the abstractHost Receptor Immunomodulation in Response to Shigella Surface Antigens: An Insight for Vaccine DevelopmentAshim K. Bagchi, Rushita A. Bagchi, Dipak K. Hens et al.Shigellosis, caused by Shigella is the most common cause of bacillary dysentery. The disease is associated with high morbidity and mortality rate owing to its multiple drug resistance. Hence recovery from the disease would primarily depend on the development of an effective immune-modulator for strong mucosal immune response. The role of cellular immunity may be a critical factor in protection … …American Journal of Immunology, Vol. 11, Issue 2 · 21 Jun 2015 · 6,752 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMicrobial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus DiseaseWei JiangThe gut mucosal barrier disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Lipo Polys Accharide (LPS). The association of enhanced microbial translocation and B cell dysfunction in HIV disease is not fully understood. High dose and short term exposure of microbial Toll-Like Receptor (TLR) agonists were used as vaccine adjuvants, however, low dose and … …American Journal of Immunology, Vol. 8, Issue 2 · 30 Jun 2012 · 7,409 accessesView PDF Cite