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12 articles for “Mark Chang”
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Research ArticleOpen accessIn the author namesMarine-Derived Extracts as Economically Sustainable and Ethical Alternatives to Fetal Bovine Serum in HEK293 Cell CultureKian Kenneth Francisco Sanchez, Jennifer Seki-Wong et al.Fetal Bovine Serum (FBS) is a staple supplement in cell culture, providing key growth factors that promote cell health and proliferation. Since 1885, cell culture has been a cornerstone of both basic and applied research, leading to significant discoveries of cell communication and function. However, the use of FBS presents economic and ethical challenges. Millions of bovine fetuses are euthanized … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 7 Aug 2026 · 1,042 accessesView PDFCite
Research ArticleOpen accessIn the author namesATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDFCite
Research ArticleOpen accessIn the author namesAn Alpha-Exhaustive Multiple Testing ProcedureMark Chang, Xuan Deng, John BalserA multiple testing procedure can be a single-step procedure such as Bonferroni's method or a stepwise procedure such as Hochberg's stepup method and Hommel's method. It can be an α-exhaustive or α-conservative approach. We develop a single α-exhaustive procedure that can improve power 2-5% over Hochberg's and Hommel's methods in common situations when the test statistics are mutually independent. The … …Current Research in Biostatistics, Vol. 6, Issue 2 · 30 Jun 2017 · 8,095 accessesView PDFCite
Research ArticleOpen accessIn the author namesTrial Design and Analysis with Incomplete Paired DataMark Chang, Jing WangFor a clinical trial design with paired data, it often involves missing observations. In such a case, the data from the trial become a mixture of paired and unpaired data. A commonly used approach for the analysis of the trial data is to ignore the incomplete pairs. Such a treatment of missing data is not statistically efficient. We propose a … …Current Research in Biostatistics, Vol. 5, Issue 2 · 12 Nov 2015 · 7,889 accessesView PDFCite
Research ArticleOpen accessIn the author namesAdaptive Superiority and Noninferiority Trial Design with Paired Binary DataMark Chang, Jing WangNon-inferiority of a diagnostic test to the standard is a common issue in medical research. For instance, we may be interested in determining if a new diagnostic test is noninferior to the standard reference test because the new test might be inexpensive to the extent that some small inferior margin in sensitivity or specificity may be acceptable. Noninferiority trials are … …Current Research in Biostatistics, Vol. 5, Issue 2 · 7 Sep 2015 · 8,236 accessesView PDFCite
Review ArticleOpen accessIn the abstractWearable Photovoltaic Applications as Energy Sources for Everyday DevicesAfonso da Silva Ravasco, Joao Paulo N. Torres, Ricardo LameirinhasSolar technology since its first implementation for energy production has evolved in numerous directions to become part of a normal reality in future energy systems. The people’s energetic consumption changed as well. In the present days, people use portable devices more than ever, such as mobile phones and laptops and to power these portable devices, batteries are used. But what … …American Journal of Engineering and Applied Sciences, Vol. 14, Issue 2 · 25 Jun 2021 · 7,462 accessesView PDFCite
EditorialOpen accessIn the abstractWhere the Future is Being Made TodayMark A. Brown, Joachim Storsberg, Christian SchmidtGrowing up, I was fascinated by The Muppet Show and the adventures of Dr. Bunsen Honeydew and his assistant Beaker. Apparently, my feelings were not unique because Muppet characters are used to ease tensions associated with education about clinical interventions (Ramsay, 2014; Rohn, 2007). Yet the opening phrase 'Where the future is being made today' has, in my opinion, summed … …American Journal of Immunology, Vol. 12, Issue 2 · 28 Jun 2016 · 7,425 accessesView PDFCite
Research ArticleOpen accessIn the abstractSELECTION OF ONTOLOGY FOR WEB SERVICE DESCRIPTION LANGUAGE TO ONTOLOGY WEB LANGUAGE CONVERSIONJ. Mannar Mannan, M. Sundarambal, S. RaghulSemantic web is to extend the current human readable web to encoding some of the semantic of resources in a machine processing form. As a Semantic web component, Semantic Web Services (SWS) uses a mark-up that makes the data into detailed and sophisticated machine readable way. One such language is Ontology Web Language (OWL). Existing conventional web service annotation can … …Journal of Computer Science, Vol. 10, Issue 1 · 12 Nov 2013 · 6,440 accessesView PDFCite
Research ArticleOpen accessIn the abstractDistribution Key in Eight Bit's Color Image AlgorithmHamdi A. Al-Omari, Malek M. Al-Nawashi, Mohammed J. BawanehProblem statement: The networked multimedia systems have glorified the necessity for image copyright protection. To solve such problem an invisible structure called watermarking is added to an 8-bits color image in aim to mark it. The structure can be added by selecting bits under certain conditions; a few pixels of correspondence between the image and the ASSCI code. Approach: In … …Journal of Computer Science, Vol. 8, Issue 1 · 25 Oct 2011 · 6,991 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordIntegrating Stochastic Properties into Traffic Flow Modeling: A Stimulus-Response ApproachKonate N’Golo, Mark Kimathi, Emile DanhoHighway traffic congestion, characterized by its inherent instability, has been extensively studied using deterministic models, providing valuable insights. However, these models often overlook the stochastic nature of driver behavior, a key factor that significantly impacts traffic flow. Recognizing this, a car-following model with discretionary lane changes to analyze their effect on traffic dynamics was introduced. While the mathematical results were … …Journal of Mathematics and Statistics, Vol. 20, Issue 1 · 19 Dec 2024 · 7,153 accessesView PDFCite