4 results for “MTHFR”

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Research ArticleOpen accessEvery word in the titleGenetic Testing for Inherited Thrombophilia in Women with Recurrent Pregnancy Loss: Prevalence and Risk Assessment of Factor V Leiden, Prothrombin, and MTHFR MutationsLina M. Al Momani, Manal A. AbbasGenetic testing for inherited thrombophilia in women with recurrent pregnancy loss (RPL) may play an important role in detecting high-risk subjects. DNA was extracted from peripheral blood leukocytes. The high pure polymerase chain reaction template preparation kit and Reverse hybridization technique were used to detect the presence of factor V (G1691A, Leiden) (FVL), Factor II (prothrombin, G20210A), and 5,10-methylenetetrahydrofolate reductase … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 29 Nov 2025 · 2,559 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleMethylenetetrahydrofolate Reductase (MTHFR) from Mediterranean to Sub-Saharan AreasRosa Chillemi, Andrea Angius, Ivana Persico et al.There are differences in the allele frequency of MTHFR polymorphism between Western and African population. The aim of this study is to determinate the prevalence of MTHFR C677T and A1298C polymorphisms in young and old people living in different areas from Mediterranean to sub-Saharan areas. The observed vs expected genotype frequencies of 677T were in Hardy Weinberg equilibrium, with the … …OnLine Journal of Biological Sciences, Vol. 6, Issue 1 · 30 Jun 2006 · 7,590 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsMethylenetetrahydrofolate Reductase (677C/T) Polymorphism in Myocardial Infarction and HypertensionHatem Al-Kordy Amin, Hanaa Fahmy Abdel Aziz, Ola Farouk Leheta, Hanan KamalHyperhomocysteinemia is a well-established risk factor for cardiovascular disease and hypertension. This study aimed to assess the MTHFR gene polymorphisms (677C/T) as a potential genetic risk factor for hypertension and Myocardial Infarction (MI) in Egypt. Myocardial infarction and hypertensive diagnosed patients were divided into two groups; first comprised 50 patients aged 45 years and a third control group comprised 84. … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 3 · 20 Sep 2012 · 8,135 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsThrombophilic Genes Mutations in Women with Repeated In-Vitro Fertilization FailureNaglaa Fathy Al Husseini, Ahmad Y. Rezk, Mosad M. Odah et al.Problem statement: Thrombophilia has been recently implicated in early pregnancy loss and IVF implantation failure, by impairing the initial vascularization process occurring at implantation, which is necessary for a successful pregnancy. Approach: The aim of this study is to assess the presence possibility of mutation in thrombophilic genes [Factor V (FV) gene, Prothrombin (PT) gene and Methylenetetrahydrofolate Reductase (MTHFR) gene] … …Current Research in Medicine, Vol. 2, Issue 1 · 29 Mar 2011 · 7,662 accessesView PDF Cite