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36 articles for “Liver Toxicity”
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Research ArticleOpen accessPhrase in the titleProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,989 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEvaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male RatsMohamed H. AhmidaProblem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,327 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCamel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino RatsFahaid Al-HashemProblem statement: Aluminum chloride (AlCl3) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel’s milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 10,367 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAroclor 1254 Toxicity to Mice Liver Membrane AtpasesShweta Pathak, Rahul KunduPresent communication reports the sub-acute dose and exposure duration dependent effects of Aroclor 1254 on total, Na+, K+, Ca++ and Mg++-ATPases of the mouse liver cells. The study tests two hypotheses, (a) whether the sublethal dose or the exposure duration dependent in vivo exposure of hydrophobic PCB (Aroclor 1254) affects the hydrophilic membrane-bound ion dependent ATPases of the liver cells … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 13 Jul 2013 · 6,791 accessesView PDFCite
Research ArticleOpen accessIn the keywordsModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Research ArticleOpen accessIn the keywordsTherapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic InflammationAhmed F. Hasan, Thulfiqar F. Mutar, Ehab Moustafa Tousson, Shatha Ghazi FelembanTricyclic Antidepressants Including Amitriptyline (AMI), stop the reabsorption of norepinephrine and serotonin, so the levels of transmitters is elevated in the brain to lead to several side effects. Therefore, current study aimed to assay liver dysfunction that attended by AMI administration and monitoring of damiana Turnera diffuse role as adjuvant therapy to improving amitriptyline hepatic effects in male rats. 60 … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 Jun 2021 · 8,286 accessesView PDFCite
Research ArticleOpen accessIn the keywordsABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATSJ. Asiedu-Gyekye Isaac, Awortwe Charles, A. Antwi DanielAllium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 30 Jan 2014 · 7,577 accessesView PDFCite
Research ArticleOpen accessIn the keywordsConcentration-Effect, Incidence and Mechanism of Nevirapine HepatotoxicityAdikwu Elias, Brambaifa NelsonNevirapine is a dipyridozepinone non nucleoside reverse transcriptase inhibitor approved for use in HIV-infected patients. Its efficacy has been well demonstrated in numerous clinical trials. It has activity against HIV-1 but does not have significant activity against HIV-2 or other retroviruses. Nevirapine is used as one of the components of highly active antiretroviral therapy in HIV patients and in the … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 19 Apr 2013 · 8,156 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHepatoprotective Effect of Vitamin EElias Adikwu, Brambaifa NelsonDrugs and some chemical agents are known to induce hepatotoxicity in humans which is of great concern to clinicians. Chemical agents are been screen daily for their hepatoprotective properties. Among these chemical agents is vitamin E which has drawn wide attention due to it reported hepatoprotective property as reported by researchers. This study collected and evaluated reports to ascertain the … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 4 · 15 Mar 2013 · 8,003 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Dietary Emamectin Benzoate at Recommended and Overdose Levels on the Pathophysiological Responses and Tolerability of Oreochromis niloticus at Fry StageJasmine Singha, Thangapalam Jawahar Abraham, Satyen Kumar Panda, Prasanna Kumar PatilEmamectin Benzoate (EB) has been recommended as a feed additive for the control of fish ectoparasites. This investigation examined the impact of dietary EB on physiological responses, antioxidant defence mechanisms, and histopathological changes in key organs, and on the kinetics of residue deposition and elimination in the muscle of Oreochromis niloticus fry. Fry were administered EB feeds at 50 µg … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 1 Jul 2026 · 1,469 accessesView PDFCite