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17 results for “Leishmaniasis”
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Research ArticleOpen accessEvery word in the titleSerological and Molecular Investigation of Cutaneous Leishmaniasis in Healthy Individuals from an American Cutaneous Leishmaniasis-Endemic RegionRejane Cristina Ribas-Silva, Taisa Rocha Navasconi, Laís de Souza Braga et al.American Cutaneous Leishmaniasis (ACL) is a major, clinically relevant zoonosis in Brazil. The disease spectrum includes single, localized, cutaneous ulcers, diffuse cutaneous leishmaniasis and mucosal disease. A subclinical form of the disease has also been described in individuals living in ACL-endemic regions. The goal of this study was to employ immunological and molecular diagnostic methods to evaluate the presence of … …American Journal of Infectious Diseases, Vol. 11, Issue 1 · 23 Jun 2015 · 7,324 accessesView PDFCite
Case ReportOpen accessEvery word in the titleRelapsing Cutaneous Leishmaniasis in a Patient Treated with HumiraErik Otte, Mikael Christiansen, Eskild PetersenLeishmanias is an anthropozoonosis caused by the Leishmania protozoa. The manifestation of the disease varies depending on the type of Leishmania and the immunestatus of the patient. Tumor Necrosis Factor (TNF)-α antagonists were introduced in the late 1990s and have had a marked impact on rheumatic diseases. Tumor necrosis factor plays an important role in the immune systems defense against … …American Journal of Infectious Diseases, Vol. 11, Issue 1 · 9 Jun 2015 · 6,881 accessesView PDFCite
Case ReportOpen accessEvery word in the titleNew World Mucocutaneous Leishmaniasis with Oral Manifestations: Case Report and Damage RepairManuel Antonio Gordón-Núñez, Stefânia Jeronimo Ferreira, Ana Luiza Dias Leite de Andrade et al.New World cutaneous leishmaniasis is an infectious and parasitic disease caused by protozoan species of the genus Leishmania. The disease is transmitted by the biteoffemaleinsects of the genus Lutzomyia and is endemic in some countries of the New World, including Bolivia, Peru and Brazil. The diagnosis of New World mucocutaneous leishmaniasis encompasses epidemiological, clinical and laboratory aspects. Usually, the combination … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 20 Feb 2015 · 7,010 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNEWER DRUGS FOR VISCERAL LEISHMANIASIS: A REVIEWKrishna Pandey, Dharmendra Singh, Sanjiva Bimal et al.Visceral Leishmaniasis (VL) is one of the most neglected tropical diseases worldwide. The diagnosis and treatment of this disease is quite complex. Sodium Antimony Gluconate (SAG) which used to be a very effective treatment has now developed resistance and is potentially a cardio-toxic drug. Pentamidine has now been discarded because of adverse effect of diabetes mellitus. Amphotericin-B is an effective … …American Journal of Infectious Diseases, Vol. 10, Issue 2 · 5 May 2014 · 7,133 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleASSOCIATION OF TESTOSTERONE AND CHOLESTEROL LEVEL IN MODULATION OF IMMUNITY AND SEVERITY OF DISEASE IN VISCERAL LEISHMANIASIS PATIENTS-A PRELIMINARY STUDYKrishna Pandey, Dharmendra Singh, Sanjiva Bimal et al.Males are more prone to Visceral Leishmaniasis (VL) as compared to females. The role of androgens in host defence against Leishmania and other pathogens is of considerable interest. This study was aimed to understand a baseline mechanistic understanding of the pathogenesis of visceral leishmaniasis with respect to testosterone. We examined the relationship between serum testosterone and cholesterol levels, antigen induced … …American Journal of Immunology, Vol. 10, Issue 1 · 25 Mar 2014 · 7,073 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAdverse Effects of Amphotericin B in Patients of Visceral Leishmaniasis: A Short Survey at Research Hospital PatnaSurabhi Bhatnagar, Shweta, Krishna Murti et al.Leishmaniasis is a disease caused by Leishmania parasite. Leishmania currently affects 12 million people in 98 countries, with an annual incidence of approximately two million new cases. Leishmaniasis is a devastating disease impairing economic productivity and impeding socioeconomic development. The objective of this article was to study the adverse effects of amphotericin B in patients of visceral leishmaniasis which was … …Current Research in Virology, Vol. 2, Issue 1 · 29 Jul 2013 · 6,815 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEpidemiological Survey of Visceral Leishmaniasis: An Evidence Based ReportMohammad Arif Khan, Ravada Vinay Kumar, Krishna Pandey et al.The aim of this study was to find out the epidemiology of visceral leishmaniasis among individuals of different age group and sex living in rural communities of Bihar, India. A retrospective study was conducted on 133 patients with a history of prolong fever and weight loss who was admitted at Rajendra Memorial Research Institute Of Medical Sciences (RMRIMS), Patna, India … …American Journal of Infectious Diseases, Vol. 9, Issue 2 · 29 Jul 2013 · 7,536 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTowards Identifying Immunogenic Targets in Visceral Leishmaniasis: Role of 17kDa and 63kDa PhosphoproteinsShubhankar K Singh, Sanjiva Bimal, Diwakar S. Dinesh et al.We observed predominant phosphorylation at Protein Kinase C (PKC-α) residue in seven immunoreactive proteins of virulent Leishmania donovani parasites. These phosphoproteins were tested for their ability to stimulate T-cells for secretion of Macrophage Migration Inhibition Factor (MIF) in comparision to crude soluble antigen in Visceral Leishmaniasis (VL) patients. Two of these phosphorylated L. donovani antigens led Leishmania to present these … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,756 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCD2 Shown to Facilitate CD4+ Cell Differentiation during Visceral Leishmaniasis, a Receptor Based StudySukrat Sinha, Shanthy Sundaram, Sanjiva Bimal et al.This study addressed the role of CD2 on CD4+ T helper cells in relation to the TCRVα1 and CD70 in two groups of BALB/c mice viz control and infected (1×107 L. donovani promastigotes). The results showed with the downregulation of CD2 expression there is a pronounced decrease of TCRVα1 and CD70 on CD4+ cells in mice. An insight into the … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 28 Nov 2015 · 7,828 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMolecular Identification of Leishmania Species in Patient with Cutaneous Leishmaniasis in an Endemic Area of Fars Province, Southern IranVahid Rahmanian, Nader Sharifi, Zahra Kargar Jahromi et al.The Cutaneous Leishmaniasis (CL) contains a range of factors, which provide different patterns of transmission that make it difficult to control. The aim of this study was to identify the different species of Leishmania in the Jahrom district of Fars province, southern Iran. This descriptive study was done on CL suspected cases who were referential to the Reference of Jahrom … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 2 · 2 Apr 2021 · 6,944 accessesView PDFCite