Research ArticleOpen accessIn the author namesBayesian Exploration of Multilocus Interactions on the Genome-Wide ScaleIvan Kozyryev, Jing ZhangProblem statement: Recent technological and scientific advances propelled the field of Genome-Wide Association Study (GWAS), which promises to be instrumental in linking many common complex diseases to their genetic origin. While so far such large-scale surveys have been moderately successful in identifying disease related genetic variants, much of disease heritability is still not accounted for by the discovered loci. There … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 2 Jul 2012 · 7,401 accessesView PDFCite
Research ArticleOpen accessIn the author namesBayesian Determination of Disease Associated Differences in Haplotype BlocksIvan Kozyryev, Jing ZhangProblem statement: While experimental ascertainment of haplotype blocks in the genome-scale case-control studies is expensive, accurate computational phasing is still a daunting task for bioinformatics approaches. We used a statistical method to determine differences, potentially associated with a certain disease, in linkage disequilibrium block boundaries in whole-genome Single Nucleotide Polymorphisms (SNPs) data. Approach: We utilized a Bayesian model for calculating … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 14 Feb 2012 · 8,423 accessesView PDFCite