232 results for “Inhibition”

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Research ArticleOpen accessEvery word in the titleRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,477 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleImpact of Ultrasonication on Milk Fat Globule Size and Inhibition of Salmonella enteritidis GrowthUmiatin Umiatin, Dalia Sukmawati, Taryudi Taryudi et al.One significant effect of ultrasonic treatment is the inactivation of microorganisms. This characteristic causes ultrasound to be widely used in food processing, healthcare devices, and water treatment. Ultrasonication is an innovative technology that holds promise for accelerating processes and producing high-quality products. The ultrasonic process in milk processing includes homogenization and sterilization. Milk homogenization standardizes fat globule size, while sterilization … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 8 May 2026 · 1,507 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleBioactivity of Sumac (Rhus Coriaria) Extract as a Green Alternative for Plant Pathogen InhibitionMohammed H. Al-Mamoori, Meisam Zargar, Elena N. Pakina, Fatih DadaşoğluEnvironmental stress caused by pathogenic fungi leads to considerable losses in global crop productivity. Plant-derived extracts are eco-friendly and sustainable alternatives that can inhibit biotic stresses. Sumac (Rhus coriaria) is widely used in industrial and medicinal applications due to its extract rich in secondary metabolites, similar to those found in chemical pesticides and pharmaceuticals. This study aimed to characterize the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 25 Nov 2025 · 2,209 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleNon-Target Inhibition of Antioxidant Enzymes in Honey Bees (A. mellifera and A. florea) Upon Pesticide ExposureAmal Ahmed Berjawi, Syed Salman Ashraf, Mohammad Ali Al-DeebUnderstanding how different insecticides influence bee health is very essential. The aim of this work was to evaluate enzyme kinetics and inhibition by insecticides in Apis mellifera and Apis florea. Tested enzymes showed variable affinity to substrates. In A. florea, glutathione S-transferase (GST) showed significantly higher affinity for its 1-Chloro-2,4-Dinitrobenzene (CDNB) substrate than in A. mellifera. Carbosulfan caused the highest … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 10 Apr 2020 · 7,394 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleInhibition of Panton-Valentine Leukocidin Toxin Induced Neutrophil Cell Lysis by Vancoplus in Methicillin-Resistant Staphylococcus Aureus InfectionsManu Chaudhary, Santosh Kumar Patnaik, Anurag PayasiPantone Valentine Leukocidin (PVL) is a cytotoxin associated with virulence of Methicillin-Resistant Staphylococcus aureus (MRSA). This study was undertaken to analyze the prevalence of PVL among MRSA strains and to study the effect of adjuvants (L-lysine, L-arginine, Ethylenediamine Tetraacetic Acid (EDTA) as well as drugs on PVL induced neutrophil cell lysis. Further, in vitro activity of Vancoplus, vancomycin, linezolid, teicoplanin … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 20 Dec 2014 · 7,106 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleSitagliptin Impairs Healing of Experimentally Induced Gastric Ulcers Via inhibition of iNOS and COX-2 ExpressionAmina Unis, Eman AbdelzaherGastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was conducted on … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 4 Sep 2013 · 7,436 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleInhibition of Skin Colour Darkening (Skin Clearing and Lightening); Skin Firming; Body Calming and Body Vitalizing Effects of Vernonia amygdalina Leaf ExtractUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Obese human subjects treated with oral Vernonia amygdalina (V. amygdalina) aqueous leaf extract for one month who experienced the anti-obesity effects of V. amygdalina leaf extract reported a lighter; clearer; more glowing and firmer skin as side effects of the treatment (unpublished findings). In this study, oral Vernonia amygdalina aqueous leaf extract was taken daily for six months … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 8,259 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleWeighted Kernel Density Estimation of the Prepulse Inhibition TestHongbo Zhou, Qiang Cheng, Hong-Ju Yang, Haiyun XuProblem statement: The goal of this study was to devise a more reliable and sensitive method for analysis of experimental data of the Prepulse Inhibition (PPI), the reduction in startle reaction towards a startle-eliciting “pulse” stimulus when it is shortly preceded by a sub-threshold “prepulse” stimulus. Approach: Different from the conventional simple averaging-based method, we proposed a probabilistic approach to … …Journal of Computer Science, Vol. 7, Issue 5 · 7 May 2011 · 7,222 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleRenal Actions of Neutral Endopeptidase Inhibition in Rats with Chronic Heart FailureAmr M. Abbas, Ayman Z. Elsamanoudy, Adel ZalataProblem statement: We aim to evaluate the effects of acute and chronic inhibition of Neutral EndoPeptidase (NEP), by ONO-9902, on plasma and renal NEP gene expression, hemodynamic and renal parameters in rats with Chronic Heart Failure (CHF) following left Coronary Artery Ligation (CAL). Approach: Forty eight male Sprague-Dawley rats (220-240 g) were divided into sham and CAL groups. Myocardial infarction … …American Journal of Applied Sciences, Vol. 7, Issue 11 · 8 Nov 2010 · 7,087 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,551 accessesView PDF Cite