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45 articles for “Hepatitis C virus”
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Research ArticleOpen accessPhrase in the titleA Cross-Sectional Study of the Prevalence of Hepatitis C Virus InfectionOmar Atrooz, Rehab Thunibat, Ihssan AtroozLiver pain is increased by hepatotropic viruses, such as the Hepatitis C Virus (HCV). This illness can progress to cirrhosis and hepatocellular cancer. This study aims to determine the prevalence of hepatitis C in the Southern Jordanian cities (Karak and Tafilah) as well as the correlations between alanine Aminotransferase (ALT), Aspartate aminotransferase (AST), age and gender in hepatitis C patients. … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 5 Jul 2024 · 4,414 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleDetection of Hepatitis C Virus Resistant Mutants in the era of Direct Acting AntiviralsLivia Maria Gonçalves Rossi, Paula RahalHepatitis C Virus (HCV) infects millions of people and represents an important public health problem in different regions of the world. Drug resistance is a major challenge for HCV-infection related control. Importantly, the arrival of a plethora of novel, more powerful drugs has revolutionized the field of HCV treatment. Here, we discuss the relevance of identification of HCV resistant mutants … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 6,429 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleInteraction of a C-terminal Truncated Hepatitis C Virus Core Protein with Plasmid DNA Vaccine Leads to in vitro Assembly of Heterogeneous Virus-like ParticlesNelson Acosta-Rivero, Joanna Poutou, Alexis Mussachio et al.Recently, it has been shown that HCV core proteins (HCcAg) with C-terminal deletions assemble in vitro into virus-like particles (VLPs) in the presence of structured RNA molecules. Results presented in this work showed that a truncated HCcAg variant covering the first 120 aa (HCcAg.120) with a 32 aa N-terminal fusion peptide (6xHistag-XpressTMepitope) interacts with plasmid DNA vaccine. Interestingly, the buoyant … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,754 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEpigenetic Mechanisms in Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Potential New Link Between Stem Cells, Virology and CancerQinghua Feng, Sajida Hassan, Trina Das et al.Recent studies suggest that epigenetic mechanisms are not only essential for the dynamic transcriptional regulation in embryonic and somatic stem cells, but are also actively involved in tumorigenesis: genes important for pluripotency are epigenetically regulated and aberrant epigenetic changes have been detected in virtually all human malignancies studied, including Hepatocellular Carcinoma (HCC). Infection with Hepatitis C Virus (HCV) is a … …Current Research in Medicine, Vol. 4, Issue 1 · 12 Mar 2013 · 8,038 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEvidences of Apoptosis in Hepatitis C Virus-Infected Hepatocytes and Peripheral Blood Monocuclear Cells in the Absence of Liver InjuryViviana Falcón, Nelson Acosta-Rivero, Mineko Shibayama et al.Understanding the mechanism of Hepatitis C Virus (HCV) pathogenesis is an important part of HCV research. In this study, the presence of apoptosis in HCV-infected liver and Peripheral Blood Mononuclear Cells (PBMC) from patients positive for anti-HCV antibodies and negative for serum HCV-RNA was investigated. The samples obtained from 21 patients were studied by in situ Hybridization (ISH), Immunofluorescence, TUNEL … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,975 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEvidences of Hepatitis C Virus Replication in Hepatocytes and Peripheral Blood Monocuclear Cells from Patients Negative for Viral RNA in SerumViviana Falcón, Nelson Acosta-Rivero, Mineko Shibayama et al.In this study, we examined the expression of hepatitis C virus (HCV) components in hepatocytes and peripheral blood mononuclear cells (PBMC) from patients positive for anti-HCV antibodies and negative for serum HCV-RNA. The samples obtained from 25 randomly selected patients (13 of 25 patients showed no histological evidences of chronic hepatitis and had normal serum ALAT and GGTP levels) were … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 7,164 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titleA Systematic Review of the Prevalence of Avian Hepatitis E Virus in Bird’s Husbandry Worldwide, 2000-2023 Prevalence of Avian Hepatitis E VirusJorge Eduardo Forero Duarte, Leonardo Alzate Mejía, Jaiberth Antonio Cardona-AriasAvian Hepatitis E virus (aHEV) constitutes a serious animal health problem and involves significant losses in poultry production; however, epidemiological evidence is scattered. Analyze the prevalence of aHEV infection in bird husbandry and its histopathological and phylogenetic characteristics based on scientific publications worldwide from 2000- 2023.Systematic review applying the Johanna Briggs Institute guidelines and the PRISMA guide. Exhaustiveness, reproducibility, and … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 4 · 27 Nov 2024 · 4,150 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDescription of Hepatitis B Virus Genotypes in Selected Groups of Subjects from Paraguay and BrazilMaría Teresa Maidana Giret, Maria Angélica Camargo Suarez, Raquel Valdovinos et al.Hepatitis B virus genotyping was conducted among 11560 healthy blood donors and haemodialysis patients in Brazil and Paraguay. Genotypes A, D and F were found in Brazil and genotypes D and F in Paraguay. This is the first report showing HBV genotype diversity in individuals in Paraguay. …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,640 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleUltrastructural Evidences of Hepatitis B Infection in Human Liver Biopsies Disclose Complex Assembly and Morphogenesis Pathways for Hepatitis B VirusViviana Falcon, Ivon Menéndez, Nelson Acosta-Rivero et al.Despite of recent advances on acknowledge of hepatitis B virus (HBV) structure and biology, little is known about the morphogenesis and release of virions. In this study, the ultrastructural analysis of HBV components in liver biopsies from chronically HBV-infected patients disclosed complex assembly and morphogenesis pathways for HBV. HBV core (HBcAg) and surface (HBsAg) antigens were specifically identified in all … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,091 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHepatitis, Meningitis and Hydrocephalus Caused by Herpes Simplex Virus Type IMiguel A. Pina, Pedro J. Modrego, F. GalveHerpes simplex virus type is the most frequent cause of sporadic and severe encephalitis in western countries. We report the exceptional case of an immunocompetent man aged 51 and who presented with hepatitis and meningitis by herpes simplex virus. Encephalitis responded to acyclovir but hepatitis did not. The patient developed diffuse hydrocephalus that required the appropriate shunt 20 days after … …American Journal of Infectious Diseases, Vol. 2, Issue 1 · 31 Mar 2006 · 7,155 accessesView PDFCite