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18 results for “Hepatic toxicity”
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Research ArticleOpen accessPhrase in the titleProtective Effect of Curcumin Against Hepatic Toxicity Induced by Lithium Carbonate (Li2 Co3)Gehan B.A. Youssef, Ahlam F. Hamoda, Rabab R. Elzoghby et al.The current work was done on four groups of rats (10 for each) to detect the hepato-protective characters of curcumin on the toxicity induced by lithium carbonate. The oral administration of Li2 Co3 for one-month lead to noticeable decrease in the SOD, CAT and GSH while the increase in the GPx and some histological changes in the portal tissues including … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 31 Jul 2019 · 7,608 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCurcuma longa, Glycyrrhiza glabra and Moringa oleifera Ameliorate Diclofenac-induced Hepatoxicity in RatsAlaaeldin A. HamzaAlthough treatment with therapeutic agents may be one of the main causes of liver toxicity, there have been only limited attempts at thorough research efforts to seek solution. Diclofenac (DIC) is a widely used anti-inflammatory drug that causes liver toxicity. This DIC-induced hepatotoxicity was found to be associated with oxidative damage. In this report, extracts of herbal plants that are … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 9,618 accessesView PDFCite
Case ReportOpen accessIn the abstractSurvival Following Severe Paraquat Poisoning a Case Study from the Andaman and Nicobar IslandsShiv Shankar Singh, Colin Sanchez, Prasan Kumar PandaParaquat poisoning continues to pose a significant public health challenge in the Andaman and Nicobar Islands, largely due to its alarmingly high mortality rate. In this report, we present the case of a 39-year-old male farmer who ingested 30 mL of paraquat with the intent of suicide. Initially, the patient underwent prompt gastric lavage and exhibited relative stability. Upon admission, … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 22 Jan 2025 · 10,617 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepato and Nephrotoxicity Caused by Sub-Chronic Exposure to Relevant Concentrations of Human Exposure to Glyphosate-Based Herbicide: An Experimental Study in RatsFernanda de Maria Serra, Letícia Rocha Magalhães, Beatriz Bertholace Magalhães Silva et al.Glyphosate's remarkable effectiveness in weed control has made it among the foremost widely employed herbicides globally. Several Glyphosate-Based Herbicides (GBHs) contain 1-4 dioxane, a compound known to induce cancer in animals and potentially contribute to liver and kidney damage in humans. The objective was to assess the liver and kidney toxicity resulting from sub-chronic exposure to GBH in rats. Eighty … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 26 Dec 2023 · 5,198 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in RatsMd. Yousuf Ali, Md. Reaz Morshed, Md. Sakib Hossen et al.In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxidant power. Administration of paracetamol (500 mg/kg) for seven consecutive days caused severe oxidative stress in … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 26 Nov 2018 · 8,341 accessesView PDFCite
Research ArticleOpen accessIn the abstractAmeliorative Impacts of Tribulus terrestris Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological StudySally I. Ismaiel, Sameh M. Farouk, Raafat A. El-Ramady, Waleed F. KhalilThe current work aimed to investigate the protective effects of Tribulus terrestris extracts against ivermectin-induced hepatic and renal toxicity in male rabbit. Selenium plus vitamin E was used as a comparative standard drug to evaluate the efficacy of Tribulus terrestris extract on some hematological parameters, kidney and liver enzymes as well as associated histopathological changes. This work was carried out … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 12 Jan 2017 · 7,771 accessesView PDFCite
Research ArticleOpen accessIn the abstractHYPOGLYCEMIC, HEPATO-RENAL AND ANTIOXIDANT POTENTIAL EFFECTS OF CHAMOMILE RECUTITA FLOWERS ETHANOLIC EXTRACT IN STREPTOZOTOCIN-DIABETIC RATSHassan Al-Musa, Fahaid AL-HashemThis study was undertaken to evaluate the hypoglycemic and hepatorenal protective effect of ethanolic extract of Chamomile recutita flowers in streptozotocin-Diabetic Rats. Before the beginning of the experiments, acute and subacute studies were carried out in control animals first to investigate the LD50 of this extract. In the experimental design, adult male albino rats were divided into five groups: (1) … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 9 Dec 2013 · 8,156 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,993 accessesView PDFCite
Research ArticleOpen accessIn the abstractPossible Mechanism of Plumbago zeylanica in Prevention of Hepatic Dammage in Wistar RatRohit Goyal, Pyare Lal SharmaPlumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kg-1, p.o.) or CCl4 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,641 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male RatsMohamed H. AhmidaProblem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,329 accessesView PDFCite