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23 results for “Heart Failure (HF)”
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Research ArticleOpen accessEvery word in the titleRenal Actions of Neutral Endopeptidase Inhibition in Rats with Chronic Heart FailureAmr M. Abbas, Ayman Z. Elsamanoudy, Adel ZalataProblem statement: We aim to evaluate the effects of acute and chronic inhibition of Neutral EndoPeptidase (NEP), by ONO-9902, on plasma and renal NEP gene expression, hemodynamic and renal parameters in rats with Chronic Heart Failure (CHF) following left Coronary Artery Ligation (CAL). Approach: Forty eight male Sprague-Dawley rats (220-240 g) were divided into sham and CAL groups. Myocardial infarction … …American Journal of Applied Sciences, Vol. 7, Issue 11 · 8 Nov 2010 · 7,087 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSoluble Tumor Necrosis Factor Receptor Type I and Dranulysin as Immunological Markers in Congestive Heart FailureSimone de Lima e Silva Deo, Maria Do Carmo Valente De Crasto, Alda Maria Da-Cruz et al.Previous studies have shown that circulating levels of cytokines are increased in patients with congestive heart failure (CHF), resulting in myocardial depression. In this work, we have determined serum levels of TNF-α and IFN-γ by ELISA, detected sTNFR-I by dot ELISA, as well as TNFα, IL-6, IL-10 and granulysin mRNA in unstimulated peripheral blood mononuclear cells (PBMC) by RT-PCR in … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,773 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMetabolic Markers of Insulin Resistance in Feline Hypertrophied Myocardium. Insulin Resistance in Heart FailureOleinikov Dmitrii ArkadievichInvestigation of myocardial tissue concentration of ATP, glucose transporters 1 and 4, pyruvate dehydrogenase, hexokinase 2, insulin receptor and adropin proteins, determining metabolic changes and possible insulin resistance in feline myocardium with hypertrophic phenotype. This is the pilot study for metabolic markers determination. Eighteen cats were studied, divided into 3 groups: Without cardiac disease (n = 5), cats with hypertrophic … …American Journal of Animal and Veterinary Sciences, Vol. 15, Issue 4 · 13 Nov 2020 · 6,327 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSome Morphologic Features of Heart Failure with Different EtiologyDmitrij Arkadievich OleynikovDilated Cardiomyopathy (DCM) and Chronical Degenerative Valvular Disease (CDVD) are very common in dogs nowadays. However, due to modern level in oncology we can meet chemotherapy-induced cardiomyopathies more often. We have lack of information about pathogenic mechanisms underlying doxorubicin-induced cardiomyopathy (DoxCM) and features differentiating it from CDVD and DCM. The study population consisted of 46 dogs of different age, sex … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 20 May 2017 · 7,330 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMetabolic Features of Heart Failure with Different EtiologyOleynikov Dmitrij ArkadievichDilated Cardiomyopathy (DCM) and Chronical Degenerative Valvular Disease (CDVD) are very common in dogs nowadays. However, due to modern level in oncology we can meet chemotherapy-induced cardiomyopathies more often. We have lack of information about pathogenic mechanisms underlying Doxorubicin-induced Cardiomyopathy (DoxCM) and features differentiating it from CDVD and DCM. In this study we investigate several metabolic features of doxorubicin-induced cardiomyopathy, … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 9 Mar 2017 · 7,172 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMMP-9 is a Potential Prognostic Marker of Left Ventricular Remodeling in Patients with Coronary Artery DiseaseMikhail Aleksandrovich Popov, Anastasia Vladimirovna Poznyak, Dmitry Valerievich Shumakov et al.Matrix Metalloproteinase-9 (MMP-9) emerges as a promising prognostic marker for assessing left ventricular remodeling in patients with coronary artery disease, particularly in the context of Ischemic Heart Disease (IHD) complicated by left ventricular aneurysm. In this study, we conducted two parallel investigations to explore the prognostic significance of MMP-9 in patients with multivessel coronary artery disease undergoing left ventricular reconstruction … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 11 Jul 2024 · 4,310 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in MiceKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methyl Glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality. Their lipid-lowering actions are by reversible and competitive inhibition of the enzyme HMG-CoA reductase, a precursor of cholesterol. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels, such as … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,679 accessesView PDFCite
Research ArticleOpen accessIn the abstractCA-LIME: A Collinearity-Aware LIME Framework for Reliable and Interpretable Explanations in Healthcare AIIdris Khan, Sachin BhoiteIn clinical tabular models, correlated biomarkers can make local explanations unstable even when predictive performance appears acceptable. This paper presents CA-LIME, a collinearity-aware extension of LIME built to address that failure mode directly. Five variations of CA-LIME Vanilla reference, VIF, PCA back projection, Ridge, and ElasticNet allow us to investigate how various correlation-control strategies alter explanation behavior. ILPD, Kaggle liver, … …Journal of Computer Science, Vol. 22, Issue 7 · 28 Jul 2026 · 806 accessesView PDFCite
Review ArticleOpen accessIn the abstractCoenzyme Q10 Supplementation Effect on Systemic DiseasesAya Jabbar HusseinThis review paper aims to examine recent RandomizedClinical Trials (RCTs) and review articles evaluating the role of CoQ10 in themanagement of atherosclerosis, and coronary heart disease, with particularfocus on Statin-Associated Muscle Symptoms (SAMS), chronic heart failure, andthe effect on cardiovascular risk factors. With an evaluation of its impacts onpatients' well‐being, it seeks to outline the existing opportunities for usingCoQ10 in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 20 Oct 2022 · 6,525 accessesView PDFCite
Research ArticleOpen accessIn the abstractEchocardiographic Pulmonary to Left Atrial Ratio in Dogs (ePLAR): A Differential Marker of Pre- and Postcapillary Pulmonary HypertensionDmitrij Oleynikov, Ma YiPulmonary Hypertension (PH) in dogs is a complicated syndrome that could be primary, due to idiopathic or genetic causes, or secondary due to pulmonary disease, pulmonary thromboembolism, heartworm disease, heart failure. Due to the inability of the routine use of right heart catheterization in veterinary patients, there is a lack of differential criteria between PH forms. This study was performed … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 1 · 17 Feb 2022 · 6,791 accessesView PDFCite