4 results for “HER2”

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Research ArticleOpen accessEvery word in the titleCrosstalk between Oxidative Stress Signaling and HER2 Pathway in Breast CancerVanessa Jacob Victorino, Adriano Martin Felis Aranome, Fernanda Carolina de Campos et al.About 20% of breast cancer patients overexpress the Human Epidermal growth factor Receptor-2 (HER2), also known as ErbB2. HER2-overexpression is associated with enhanced tumor malignancy and its overexpression is related to specific target therapy against breast tumors and other cancers. HER2-mediated pathways in tumor cells act on behalf of the tumor conferring aggressive characteristics. Several reports demonstrated the occurrence of … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,038 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleHER2 Protein Overexpression in Infiltrating Ductal Carcinoma of the Breast Associated with Lymph Node InvolvementAdrienne Pratti Lucarelli, Maria Marta Martins, Vilmar Marques Oliveira et al.The current study compares the rates of overexpression of the HER2 protein in stage II ductal carcinoma of breast in patients with lymph-node involvement. The research material was tissue sections obtained from the primary tumor of 28 patients with lymph-node involvement. The technique used to detect the protein was immunohistochemistry. The overexpression of HER2 protein occurred in 33.3% of lymph … …American Journal of Applied Sciences, Vol. 6, Issue 3 · 31 Mar 2009 · 7,121 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsP53 Gene: Mutation and Immunohistochemical Analysis in Patients with Invasive Ductal Carcinoma of BreastShinjini Singh, Sandeep Kumar Rajput, Mritunjai Singh et al.The p53 tumor suppressor gene is the most commonly mutated gene in cancer. In breast cancer, the presence of p53 gene alterations has been associated with worse prognosis. This study was attempted to associate p53 gene mutations with its protein expression in North Eastern Indian population. We used single-stranded conformation polymorphism to screen samples for mutations in five conserved regions, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 7,244 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEarly Diagnosis of Breast Cancer using Molecular, Biochemical and Pathological MarkersSalah El-Din El-Assal, Adel A. El-Tarras, Samir M. Abd-allaProblem statement: Laboratory diagnosis of breast cancer in most of the hospitals has traditionally been performed using cell culture and the direct hormone receptor assay, which are money and time consuming. Approach: This study was performed in order to direct the attention toward increasing the efficiency of early diagnosis in clinical laboratories at the western region of KSA and Egypt … …American Journal of Applied Sciences, Vol. 8, Issue 1 · 31 Jan 2011 · 8,056 accessesView PDF Cite