7 results for “H1N1 Virus”

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Research ArticleOpen accessPhrase in the titleIN SILICO DESIGN OF THE M2 PROTON CHANNEL INHIBITORS OF H1N1 VIRUSUsman Sumo Friend Tambunan, Mochamad Reza Rahdiansyah, Arli Aditya ParikesitM2 proton channel of H1N1 Influenza A virus is the target protein anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The resistance of influenza A virus to amantadine need to develop more effective adamantane-based drugs. Several research by molecular docking method have been … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 5 Jan 2013 · 7,999 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleDesigning of Disulfide Cyclic Peptide for Inhibiting Polymerase A and B1 (PAC-PB1N) in H1N1 Virus using Molecular Simulation ApproachUsman Sumo Friend Tambunan, Mochammad Arfin Fardiansyah Nasution, Arli Aditya Parikesit et al.The drug resistance A/H1N1 flu virus is emerging rapidly. Therefore, looking for potential therapy is very important. PB2, PB and PA are subunits of viral RNA-dependent RNA polymerase (RdRp). They play an important role in viral replication. The PA and PB1 binding sites can be considered as potential targets for the development of new influenza drugs. The peptide inhibitors can … …OnLine Journal of Biological Sciences, Vol. 16, Issue 3 · 24 Aug 2016 · 7,310 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAn Informetric Analysis of Studies on Influenza Vaccines and VaccinationVadim Nikolaevich Gureyev, Nikolay Alekseevich Mazov, Tatyana Nikolaevna Ilyicheva, Sergei Ivanovich BazhanInfluenza is one of highly contagious acute virus diseases that primarily affects respiratory ways. Annual seasonal epidemics afflict approximately 15% population worldwide and lead to 250,000–500,000 deaths each year. That is why studies on influenza vaccines and vaccination that prevent spreading of the virus remain highly important. This paper presents the results of informetric analysis of publications on influenza vaccine … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 13 Dec 2017 · 7,274 accessesView PDF Cite

Research ArticleOpen accessIn the abstractGenomic Signature of Respiratory Microbes on Human Scalp EpitheliaBhola Nath Paul, Vani Mishra, Jasmeet Kaur Chhabra, Divyani PaulDespite overlap between habitats occupied by diverse Airborne Respiratory Microbes (ARM), the airway epithelium is known for respiratory microbe infections, human scalp epithelium is undocumented. Analogous to airways epithelium, the scalp epithelium is vulnerable to infection by dormant variants of sensitive microbes that underlie many chronic and relapsing diseases, difficult to eradicate by conventional antibiotics and challenged our ability to … …American Journal of Immunology, Vol. 11, Issue 3 · 11 Sep 2015 · 7,074 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMOLECULAR CHARACTERIZATION ON THE BASIS OF HA, NA AND M GENE REVEALED CHANGES IN CRITICAL AMINO ACID POSITIONS OF INFLUENZA A (H3N2) VIRUS CIRCULATING IN INDIA DURING 2011-2013Sachin Kumar, Shashi Khare, Bano Saidullah et al.Influenza a (H1N1) virus is responsible for acute respiratory infection in human, which occasionally causes epidemic and rarely a pandemic. Full length DNA sequencing of HA, NA and M gene of H3N2 virus from year 2011-2013 was performed for determination of the circulating strains in India along with monitoring status of various mutations associated with drug resistance and virulence. Genetic … …American Journal of Infectious Diseases, Vol. 10, Issue 3 · 18 Oct 2014 · 6,839 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInfluenza Surveillance in Russia Based on Epidemiological and Laboratory Data for the Period from 2005 to 2012Sominina Anna, Elena Burtseva, Mikhail Eropkin et al.Exchange of information on and sharing of influenza viruses through the GISRS network has great significance for understanding influenza virus evolution, recognition of a new pandemic virus emergence and for preparing annual WHO recommendations on influenza vaccine strain composition. Influenza surveillance in Russia is based on collaboration of two NICs with 59 Regional Bases. Most epidemiological and laboratory data are … …American Journal of Infectious Diseases, Vol. 9, Issue 3 · 14 Oct 2013 · 8,759 accessesView PDF Cite

Research ArticleOpen accessIn the abstractBioactive Compounds Screening from Zingiberaceae Family as Influenza A/Swine Flu Virus Neuraminidase Inhibitor through Docking ApproachUsman Sumo Friend Tambunan, Fadilah, Arli Aditya ParikesitProblem statement: Influenza A/H1N1 is a disease caused by infection of influenza a virus subtype H1N1. It is a major health problem in tropical and subtropical countries. This virus constantly mutates and consequently will be developed into new drug-resistant strains. Approach: In this research, we have conducted docking study to screen bioactive compounds from Zingiberaceae family, which has a role … …OnLine Journal of Biological Sciences, Vol. 10, Issue 4 · 31 Dec 2010 · 8,616 accessesView PDF Cite